947380-09-8

Basic information

• Product Name: 5-(2-methoxy-ethoxy)-1H-indole
• CAS NO: 947380-09-8
• Molecular Weight: 191.23
• Mol File: 947380-09-8.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 5-(2-methoxy-ethoxy)-1H-indole(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(2-methoxy-ethoxy)-1H-indole(947380-09-8)
• EPA Substance Registry System: 5-(2-methoxy-ethoxy)-1H-indole(947380-09-8)

Safety Data

• Hazardous Substances Data: 947380-09-8(Hazardous Substances Data)

Upstream product

• 5815-08-7 tert-Butoxybis(dimethylamino)methane 
• 1026179-29-2 4-(2-Methoxy-ethoxy)-2-methyl-1-nitro-benzene 
• 1953-54-4 indol-5-ol 
• 4296-15-5 2-iodo-1-methoxyethane 
• 6482-24-2 2-Bromoethyl methyl ether 
• 2581-34-2 3-methyl-4-nitrophenol 

Relevant articles and documents

INDOLE COMPOUNDS OR ANALOGUES THEREOF USEFUL FOR THE TREATMENT OF AGE-RELATED MACULAR DEGENERATION (AMD)

The present invention provides a compound of formula (I): a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

TETRACYCLIC INDOLOPYRIDINES AS EG5 INHIBITORS

Compounds of a certain formula (I), in which R1, R2, R3 and R4 have the meanings indicated in the description, are effective Eg5-inhibiting compounds with anti-proliferative and/or apoptosis inducing activity.

The serotonin 5-HT4 receptor. 2. Structure-activity studies of the indole carbazimidamide class of agonists.

A number of substituted indole carbazimidamides were prepared and evaluated as 5-HT4 receptor agonists by using the isolated field-stimulated guinea pig ileum preparation. Their selectivity for the 5-HT4 receptor was established by examining their affinity for other 5-HT receptors using radioligand-binding techniques. Several selective and highly potent full as well as partial agonists emerged from this study. For example, 1b,d were found to be the most potent, full 5-HT4 receptor agonist described so far (EC50 = 0.5 and 0.8 nM, respectively), being 6 and 4 times more potent than serotonin itself. On the other hand, 5b and 1h appeared as partial 5-HT4 receptor agonists in the nonstimulated guinea pig ileum preparation with potencies, evaluated against serotonin action, respectively similar (5b, Ki = 12 nM) to and 300-fold higher (1h, Ki = 0.04 nM) than serotonin.