94741-66-9Relevant academic research and scientific papers
Design, synthesis and biological evaluation of potent NAD +-dependent DNA ligase inhibitors as potential antibacterial agents. Part I: Aminoalkoxypyrimidine carboxamides
Gu, Wenxin,Wang, Tiansheng,Maltais, Francois,Ledford, Brian,Kennedy, Joseph,Wei, Yunyi,Gross, Christian H.,Parsons, Jonathan,Duncan, Leonard,Ryan Arends,Moody, Cameron,Perola, Emanuele,Green, Jeremy,Charifson, Paul S.
scheme or table, p. 3693 - 3698 (2012/07/27)
A series of 2,6-disubstituted aminoalkoxypyrimidine carboxamides (AAPCs) with potent inhibition of bacterial NAD+-dependent DNA ligase was discovered through the use of structure-guided design. Two subsites in the NAD+-binding pocket were explored to modulate enzyme inhibitory potency: a hydrophobic selectivity region was explored through a series of 2-alkoxy substituents while the sugar (ribose) binding region of NAD+ was explored via 6-alkoxy substituents.
