947546-62-5

Basic information

• Product Name: 1-bromo-5-trifluoromethyl-2-(prop-1-ynyl)benzene
• Synonyms: 1-bromo-5-trifluoromethyl-2-(prop-1-ynyl)benzene
• CAS NO: 947546-62-5
• Molecular Weight: 263.057
• Mol File: 947546-62-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1-bromo-5-trifluoromethyl-2-(prop-1-ynyl)benzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-bromo-5-trifluoromethyl-2-(prop-1-ynyl)benzene(947546-62-5)
• EPA Substance Registry System: 1-bromo-5-trifluoromethyl-2-(prop-1-ynyl)benzene(947546-62-5)

Safety Data

• Hazardous Substances Data: 947546-62-5(Hazardous Substances Data)

Upstream product

• 590-15-8 trans-2-propenyl bromide 
• 481075-58-5 2-bromo-1-iodo-4-(trifluoromethyl)benzene 
• 1048326-32-4 5-trifluoromethyl-2-(prop-1-ynyl)aniline 
• 16466-97-0 1-propynylmagnesium bromide 

Downstream Products

• 947546-63-6 C₁₀H₆F₃I 
• 947546-12-5 1,2-bis[2-(prop-1-ynyl)-4-(trifluoromethyl)phenyl]ethyne 

Relevant articles and documents

Enantioselective Synthesis of Distorted π-Extended Chiral Triptycenes Consisting of Three Distinct Aromatic Rings by Rhodium-Catalyzed [2+2+2] Cycloaddition

The enantioselective synthesis of distorted π-extended chiral triptycenes, consisting of three distinct aromatic rings, has been achieved with high ee value of 87 % by the cationic rhodium(I)/segphos complex-catalyzed enantioselective [2+2+2] cycloaddition of 2,2′-di(prop-1-yn-1-yl)-5,5′-bis(trifluoromethyl)-1,1′-biphenyl with 6-methoxy-1,2-dihydronaphthalene followed by the diastereoselective Diels–Alder reaction and aromatization. Demethoxy derivatives were also synthesized by the C?O bond cleavage. In this synthesis, the use of the electron-deficient diyne and the electron-rich alkene is crucial to suppress the undesired strain-relieving carbocation rearrangement and stabilize the distorted triptycene structure.

PtCl2-catalyzed hydrative cyclization of trialkyne functionalities to form bicyclic spiro ketones

(Chemical Equation Presented) Triple rounds: A regioselective hydrative cyclization of triynes has been developed to give bicyclic β-hydroxy spiro ketones, which undergo subsequent dehydration to give the β,γ- unsaturated ketones (see scheme). Model reactions suggest that this platinum catalysis includes two selective hydrations, an alkyne insertion, and an aldol condensation.