94816-48-5

Upstream product

• 59662-65-6 methylthiomethyl p-tolyl sulfone 
• 74-88-4 methyl iodide 

Downstream Products

• 118721-48-5 1-chloro-1-methylthio-1-(p-toluenesulfonyl)ethane 
• 1061868-29-8 C₁₀H₁₃FO₂S₂ 
• 1061868-42-5 C₁₀H₁₃FO₂S₂ 
• 1220996-55-3 C₂₀H₃₆O₃S₂Si 
• 1220996-70-2 C₁₁H₁₆O₃S₂ 
• 107951-80-4 1-Methyl-4-(2-methylsulfanyl-1-phenyl-propane-2-sulfonyl)-benzene 
• 173959-53-0 2-[2-Chloro-2-methylsulfanyl-2-(toluene-4-sulfonyl)-ethyl]-malonic acid diethyl ester 
• 173959-52-9 2-[2-Methylsulfanyl-2-(toluene-4-sulfonyl)-ethyl]-malonic acid diethyl ester 
• 118721-49-6 1-(methylthio)-1-[(4-methylphenyl)sulfonyl]ethene 

Relevant academic research and scientific papers

Novel synthesis of γ-lactones starting from β,γ-unsaturated carboxylic esters

A novel synthetic route to highly substituted γ-lactones was achieved by an intermolecular radical addition to 4-(methylthio)-4-(p-tolylsulfonyl)-3-butenoic ester (1) and its 2-(ethoxycarbonyl) derivative (2), which were easily prepared from (methylthio)methyl p-tolyl sulfone. Upon the irradiation of a solution of 1 and benzophenone in an alcohol (R1R2CHOH), the 1-hydroxyalkyl radical (R1R2C-OH) was generated and added regiospecifically to the 3-position of 1 to form an adduct that led to a γ-lactone by spontaneous intramolecular condensation. Similarly, 2 reacted with the alcohol to give α-(ethoxycarbonyl)-γ-lactones. The alcohol, which is a high boiling liquid or solid, can be employed in the form of a solution (10 molar amounts in acetonitrile) without greatly lowering the reaction efficiency.

PROTEIN PHOSPHATASE INHIBITOR

Provided is a novel protein phosphatase inhibitor. The protein phosphatase inhibitor contains, as an active ingredient, a silicon compound represented by the following general formula (1) or a salt thereof, wherein R1, R2 and R3 are the same or different and represent a hydrocarbon group having 1 to 12 carbon atoms; X represents an optionally substituted hydrocarbon group having 3 to 36 carbon atoms or an optionally substituted heterocyclic group; and n represents an integer of 0 or 1.