948289-14-3

Basic information

• Product Name: 6-BROMO-2-METHYLQUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER
• Synonyms: 6-BROMO-2-METHYLQUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER;Ethyl 6-bromo-2-methylquinoline-3-carboxylate;6-Bromo-2-methylquinoline-3-carboxylicacidethyleste
• CAS NO: 948289-14-3
• Molecular Formula: C₁₃H₁₂BrNO₂
• Molecular Weight: 294.14
• Mol File: 948289-14-3.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 358.5°C at 760 mmHg
• Flash Point: 170.6°C
• Appearance: /
• Density: 1.444g/cm³
• Vapor Pressure: 2.54E-05mmHg at 25°C
• Refractive Index: 1.615
• CAS DataBase Reference: 6-BROMO-2-METHYLQUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 6-BROMO-2-METHYLQUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER(948289-14-3)
• EPA Substance Registry System: 6-BROMO-2-METHYLQUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER(948289-14-3)

Safety Data

• Hazard Codes: Xi
• Statements: 41
• Safety Statements: 26-39
• WGK Germany: 3
• Hazardous Substances Data: 948289-14-3(Hazardous Substances Data)

Usage

Description

6-BROMO-2-METHYLQUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER is a chemical compound with the molecular formula C13H11BrN2O2, belonging to the quinoline family. It is a yellow crystalline powder that is sparingly soluble in water but soluble in organic solvents. Due to its potential to cause irritation to the skin, eyes, and respiratory system, careful handling is required.
Used in Pharmaceutical Industry:
6-BROMO-2-METHYLQUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER is used as an intermediate for the synthesis of various drugs, contributing to the development of new pharmaceuticals.
Used in Agrochemical Industry:
6-BROMO-2-METHYLQUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER is used as a building block for the synthesis of agrochemicals, playing a role in the creation of products for agricultural applications.
Used in Research Chemicals:
6-BROMO-2-METHYLQUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER is used as a research chemical, aiding scientists in their studies and experiments to advance knowledge in various chemical and biological fields.

InChI:InChI=1/C13H12BrNO2/c1-3-17-13(16)11-7-9-6-10(14)4-5-12(9)15-8(11)2/h4-7H,3H2,1-2H3

Upstream product

• 29124-57-0 2-amino-5-bromobenzaldehyde 
• 141-97-9 ethyl acetoacetate 
• 20712-12-3 (2-amino-5-bromophenyl)methanol 
• 5794-88-7 5-Bromo-2-aminobenzoic acid 
• 20357-20-4 5-bromo-2-nitrobenzaldehyde 

Downstream Products

• 1020576-36-6 ethyl 6-[4-({[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methyl}oxy)phenyl]-2-methyl-3-quinolinecarboxylate 

Relevant articles and documents

Lewis Acid-Catalyzed C(sp3)–C(sp3) Bond Forming Cyclization Reactions for the Synthesis of Tetrahydroprotoberberine Derivatives

An efficient Lewis acid-catalyzed C(sp3)–C(sp3) bond forming annulation reaction has been developed. This strategy serves as a new method for the facile synthesis of tetrahydro-5H-isoquinolino[2,1-g][1,6]naphthyridine derivatives. A wide range of 2-methylquinoline-3-carbaldehydes and 1,2,3,4-tetrahydroisoquinolines can be applied for this process to afford structurally diverse tetrahydroprotoberberine derivatives in excellent yields. (Figure presented.).

Acetic Acid Promoted Redox Annulations with Dual C-H Functionalization

Amines such as 1,2,3,4-tetrahydroisoquinoline undergo redox-neutral annulations with 2-alkylquinoline-3-carbaldehydes as well as the corresponding 4-alkyl isomers and pyridine analogues. These processes involve dual C-H bond functionalization. Acetic acid