94835-10-6Relevant articles and documents
THE 2-(DIPHENYLPHOSPHINO)ETHYL GROUP (DPPE) AS A NEW CARBOXYL-PROTECTING GROUP IN PEPTIDE CHEMISTRY
Chantreux, Dominique,Gamet, Jean-Paul,Jacquier, Robert,Verducci, Jean
, p. 3087 - 3094 (2007/10/02)
The use of 2-(diphenylphosphino)ethyl group for carboxyl-protection of amino acids or peptides is described.This group is easily introduced by esterification using 2-(diphenylphosphino)ethanol in the presence of dicyclohexylcarbodiimide and 4-(dimethylamino)pyridine.These Dppe esters are stable under the standard conditions for peptide synthesis.Deprotection is carried out under mild conditions by quaternisation using methyl iodide followed by a β-elimination induced by fluoride ion or potassium carbonate.