94838-70-7Relevant academic research and scientific papers
A novel aromatic alkylation of anilines with cyclic and acyclic ketones under hydrothermal conditions
Mehta, Barun K.,Kumamoto, Koji,Yanagisawa, Kazumichi,Kotsuki, Hiyoshizo
, p. 6953 - 6956 (2007/10/03)
A novel aromatic ring-alkylation was achieved by condensation between aniline-HCl salts and cyclic or acyclic ketones under hydrothermal conditions.
Synthesis of Certain Mesogenic Azomethines Derived from 4-Cycloalkylanilines and from 4-Cycloalkylbenzaldehydes
Byron, D. J.,Matharu, A. S.,Rees, M.,Wilson, R. C.
, p. 229 - 238 (2007/10/02)
General procedures are described for the synthesis of members of five pairs of related homologous series of mesogenic azomethines differing in the mode of linkage of the CH=N group and containing a cycloalkyl group in a terminal position.
Synthesis and evaluation of 4-alkylanilines as mammary tumor inhibiting aromatase inhibitors
Hartmann,Batzl
, p. 537 - 544 (2007/10/02)
The 4-alkylanilines 1-20 were synthesized to elucidate the importance of the glutarimide moiety for the aromatase inhibiting activity of aminoglutethimide [3-(4-aminophenyl)-3-ethylpiperidine-2,6-dione, AG], the only non-steroidal aromatase inhibitor which is commercially available at present. The most interesting compounds were the (4-aminophenyl)cycloalkanes 4-6 (4, c-pentyl; 5, c-hexyl; 6, c-heptyl) and the 1-alkyl-1-(4-aminophenyl)cyclohexanes 1-3 (1, CH3; 2, C2H5; 3, n-C3H7). Derivatives 1-6 are stronger inhibitors of human placental aromatase than AG exhibiting relative potencies from 1.5 to 2.7 (AG≡1). For selectivity of action, the inhibition of desmolase (cholesterol side chain cleavage enzyme) was determined. Compounds 1-3 showed an inhibition comparable to AG, whereas compounds 4-6 exhibited no effect on desmolase. Being more potent and selective aromatase inhibitors in vitro, compounds 4-6, however, were not superior to AG in vivo, when the reduction of plasma estradiol concentration and the tumor inhibiting activity (PMSG-primed SD rats and DMBA-induced mammary carcinoma of the SD rat, postmenopausal model) were concerned.
