94851-97-5Relevant academic research and scientific papers
Cyclization into perhydronaphthalenones using samarium diiodide
Sono, Masakazu,Onishi, Sachiko,Tori, Motoo
, p. 3385 - 3395 (2007/10/03)
Samarium(II) diiodide has been employed to promote the intramolecular cyclization reactions of aldehydes or ketones onto α,β-unsaturated ketones. The cyclization reactions described herein provide a general approach to the syntheses of perhydronaphthalenones with a cis-relationship between the OH at C-5 and the proton or methyl group at C-4a with good diastereoselectivity under mild reaction conditions.
REMARKABLE STEREOCONTROL OBSERVED IN THE RING FORMATION BY INTRAMOLECULAR HOSOMI-SAKURAI REACTION
Tokoroyama, Takashi,Tsukamoto, Masamitsu,Iio, Hideo
, p. 5067 - 5070 (2007/10/02)
The cyclization of 2-(3',4'-dimethyl-6'-trimethylsilyl-4'-hexenyl)-2-cyclohexenone with TiCl4 afforded stereospecifically 6α,7α-dimethyl-6β-vinyl-5βH-1-decalone derivate and the two-fold diastereoselection involved is reasoned in terms of orientation control and folding strain control.
