94878-34-9

Upstream product

• 59-48-3 2-oxoindole 
• 119-61-9 benzophenone 
• 220466-11-5 1-isocyanato-2-(2-phenylethynyl)benzene 
• 98-80-6 phenylboronic acid 
• 3240-34-4 [bis(acetoxy)iodo]benzene 
• 7342-02-1 3-phenylpropynoic acid phenylamide 
• 91-01-0 1,1-Diphenylmethanol 
• 208845-12-9 3-phenylpropynoic acid (2-iodo-phenyl)-amide 

Downstream Products

• 100025-50-1 3',3'-diphenyl-1H-spiro[indole-3,2'-oxiran]-2-one 
• 1370728-15-6 3-benzhydrylindolin-2-one 
• 1273323-29-7 methyl 3-((3-(diphenylmethylene)-2-oxoindolin-1-yl)methyl)benzoate 
• 105765-55-7 1-benzhydryl-3',3'-diphenyl-1H-spiro[indole-3,2'-oxiran]-2-one 

Relevant academic research and scientific papers

Activating Effect of 3-Benzylidene Oxindoles on AMPK: From Computer Simulation to High-Content Screening

AMP-activated protein kinase (AMPK) is currently the subject of intensive study and active discussions. AMPK performs its functions both at the cellular level, providing the switch between energy-consuming and energy-producing processes, and at the whole

Luminescent material having aggregation-induced emission property as well as preparation and application thereof

The invention belongs to the technical field of luminescent materials, and discloses a luminescent material having aggregation-induced emission property as well as preparation and application thereof.A molecular general formula of the luminescent material is as shown in a formula I which is shown in the description, wherein R1 and R2 are different or same electron donating or electron withdrawinggroups, and R3 and R4 are simultaneously hydrogen or methoxy groups. The luminescent material disclosed by the invention is stable in structure, has the aggregation-induced emission property and is good in luminescent performance, and the highest efficiency of crystalline-state fluorescent quanta can be up to 20.7 percent; meanwhile, a preparation method of the luminescent material is simple in operation, gentle in reaction conditions and high in reaction yield; the luminescent material has the advantages that solid-state luminescence can be realized, the cost of raw materials is low, regeneration is realized, regulation of light color can be easily realized through accessing different electron donating and electron withdrawing groups, and the like, and the luminescent material is beneficial for large-scale popularization, and the problem of energy depletion is solved; meanwhile, the luminescent material has mechanoluminescence property, and can be applied to the fields of fake prevention, real-time pressure change monitoring and the like. The formula is shown in the description.

Advanced palladium free approach to the synthesis of substituted alkene oxindoles: Via aluminum-promoted Knoevenagel reaction

A synthetic route for the synthesis of C24, as well as for the design of focused libraries of direct AMPK activators was developed based on a convergent strategy. The proposed scheme corresponds to the current trends in C-H bond functionalization. The use of aluminum isopropoxide for the Knoevenagel condensation of oxindole with benzophenones is a noticeable point of this work.

Ru-Catalyzed dehydrogenative synthesis of antimalarial arylidene oxindoles

Ru(ii)-NHC catalyzes α-olefination of 2-oxindoles using diaryl methanols in the absence of an acceptor. A wide array of symmetrical and unsymmetrical diaryl methanols undergoes dehydrogenative coupling with 2-oxindole selectively to generate various substituted 3-(diphenylmethylene)indolin-2-one derivatives in good yields and produces environmentally benign by-products, H2 and H2O. This methodology was successfully applied for the synthesis of a bioactive drug i.e. TAS-301. The biological activities of the synthesized 3-(diphenylmethylene)indolin-2-one derivatives were screened against the Plasmodium falciparum parasite and found to exhibit a significant activity with IC50 = 2.24 μM.

An expedient synthesis of 3-alkylideneoxindoles by Ti(OiPr) 4/pyridine-mediated Knoevenagel condensation

3-Alkylideneoxindoles have been prepared in excellent yields from oxindole and carbonyl compounds via an in situ generated titanium enolate of oxindole. (Z)-3-Alkylideneoxindoles could be synthesized selectively as major products from unsymmetrical ketones.

A Facile Method for the Synthesis of 3-Alkyloxindole

Benzylamine in combination with acetic acid was identified as a powerful catalyst for the condensation of oxindole with aldehydes, acetone or cyclic ketones. A variety of 3-alkyloxindoles could be readily prepared in 10 mmol scale via the sequential benzylamine acetate catalyzed condensation of oxindoles with aldehydes (or ketones) and conjugate reduction by NaBH4.

Palladium-catalyzed C-H functionalization of N-arylpropiolamides with aryliodonium salts: Selective synthesis of 3-(1-arylmethylene)oxindoles

(Chemical Equation Presented) A selective and efficient method for the synthesis of 3-(1-arylmethylene)oxindoles by palladium-catalyzed C-H functionalization of anilides with aryliodonium salts has been developed. In the presence of Pd(OAc)2 and Et3N, a variety of anilides underwent the reaction with aryliodonium salts to afford the corresponding 3-(1-arylmethylene)oxindoles in moderate to good yields. It is noteworthy that the reaction can be conducted providing moderate yields even without bases. The mechanism of the reaction was also discussed.

Stereoselective synthesis of 3-alkylideneoxindoles by rhodium-catalyzed cyclization reaction of 2-alkynylaryl isocyanates with aryland alkenylboronic acids

The rhodium-catalyzed cyclization reaction of 2-alkynylaryl isocyanates with aryl- and alkenylboronic acids furnishes 3-alkylideneoxindoles in a stereoselective manner. The reaction allows arrangement of various substituents on the exocyclic double bond a

A tandem heck-carbocyclization/suzuki-coupling approach to the stereoselective syntheses of asymmetric 3,3-(diarylmethylene)indolinones

(Chemical Equation Presented) An efficient and versatile method for stereoselective synthesis of (E)-3,3-(diarylmethylene)indolinones by a palladium-catalyzed tandem Heck-carbocyclization/Suzuki-coupling sequence is presented. Factors influencing yield and selectivity, namely catalyst, coordinating ligand, and solvent, are detailed.

Potassium fluoride on alumina: Dry synthesis of 3-arylidene-1,3-dihydro- indol-2-one under microwave irradiation

Aldehydes (2) or ketones (4) were condensed with 1,3-dihydro-indol-2- one (1) in presence of potassium fluoride on alumina without solvent under focused microwave irradiation.