948891-47-2Relevant academic research and scientific papers
Dual-specificity phosphatase CDC25A/B inhibitor identified from a focused library with nonelectrophilic core structure
Tsuchiya, Ayako,Hirai, Go,Koyama, Yusuke,Oonuma, Kana,Otani, Yuko,Osada, Hiroyuki,Sodeoka, Mikiko
supporting information; experimental part, p. 294 - 298 (2012/07/28)
Focused libraries of enamine derivatives with a nonacidic, nonelectrophilic core structure were screened for inhibitors of dual-specificity protein phosphatases, and an o-hydroxybenzyl derivative RE44 (10d) was identified as a selective inhibitor of CDC25A/B. This inhibitor induced cell-cycle arrest of tsFT210 cells at the G2/M phase and inhibited dephosphorylation of the CDC25B substrate CDK1. Unlike most quinone-based inhibitors, 10d does not generate reactive oxygen species.
