94906-06-6Relevant academic research and scientific papers
Synthesis of Mannich-type derivatives from amides activated by hydrogen bonding with ZnCl2
Gong, Bozhen,Hu, Zhiyu,Jiang, Guofang,Le, Zhanggao,Xie, Zongbo,Zhu, Zhiqiang
, p. 9095 - 9099 (2020)
The amide group has one of the most significant functionalities found in many natural products. Herein, low-nucleophilic amides are used in a Mannich-type reaction to synthesize N-acyl-protected amine derivatives. A highly efficient synthetic method utilizing simple aldehydes, N-substituted anilines, and amides as substrates was established through a one-pot amide pathway activated by hydrogen bonding between the ZnCl2 and amide under solvent-free conditions. This strategy can be broadly applied to medicinal chemistry. More importantly, compared with the previous Lewis acid catalyzed reaction, we proposed a new application of zinc chloride. This journal is
Preparation method of amide-containing Mannich type compound
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Paragraph 0022-0032; 0265, (2021/02/06)
The invention discloses a preparation method of an amide-containing Mannich type compound, which mainly comprises the following steps of mixing and stirring aldehyde, N-substituted aniline, an amide compound and zinc chloride at 80 DEG C, and carrying out after-treatment after the reaction is finished, thereby obtaining the product. The aldehyde has a structure as shown in a compound 1, and R1 isselected from aryl or alkyl; the N-substituted aniline has a structure as shown in a compound 2, R2 and R3 are respectively and independently selected from aryl, H or alkyl, the amide has a structureas shown in a compound 3, R4 is selected from aryl or alkyl, and X is S or O. According to the preparation method, cheap zinc chloride is used, a reaction is carried out under mild conditions, the operation process is simple and environmentally friendly, and the preparation method has application and popularization value.
