949168-34-7

Upstream product

• 61150-57-0 2-bromo-4-fluorobenzyl bromide 
• 61150-58-1 2-(2-bromo-4-fluorophenyl)acetonitrile 

Downstream Products

• 1069115-02-1 methyl 2-(2-bromo-4-flurophenyl)-2-methylpropanoate 
• 1103768-21-3 methyl 2-(2-bromo-4-fluorophenyl)-2-formylacetate 
• 1340079-04-0 2-(2-bromo-4-fluorophenyl)acetaldehyde 
• 59142-68-6 2-bromo-4-fluorobenzaldehyde 

Relevant academic research and scientific papers

Chiral Magnesium Bisphosphate-Catalyzed Asymmetric Double C(sp3)-H Bond Functionalization Based on Sequential Hydride Shift/Cyclization Process

Described herein is a chiral magnesium bisphosphate-catalyzed asymmetric double C(sp3)-H bond functionalization triggered by a sequential hydride shift/cyclization process. This reaction consists of stereoselective domino C(sp3)-H bond functionalization: (1) a highly enantio- and diastereoselective C(sp3)-H bond functionalization by chiral magnesium bisphosphate (first [1,5]-hydride shift), and (2) a highly diastereoselective C(sp3)-H bond functionalization by an achiral catalyst (Yb(OTf)3, second [1,5]-hydride shift).

TRIAZOLE AGONISTS OF THE APJ RECEPTOR

Compounds of Formula I and Formula II, pharmaceutically acceptable salt thereof, stereoisomers of any of the foregoing, or mixtures thereof are agonists of the APJ Receptor and have use in treating cardiovascular and other conditions. Compounds of Formula I and Formula II have the following structures where the definitions of the variables are provided herein.