949489-22-9

Upstream product

• 949489-15-0 p-tolyl 2-O-benzoyl-3,4,6-tri-O-benzyl-β-D-galactopyranosyl-(1->3)-2-azido-4,6-O-benzylidene-2-deoxy-1-thio-β-D-galactopyranoside 
• 125760-23-8 4-methylphenyl 2-azido-4,6-O-benzylidene-2-deoxy-1-thio-β-D-galactopyranoside 
• 125760-22-7 p-methylphenyl 2-deoxy-2-azido-1-thio-β-D-galactopyranoside 
• 106-45-6 para-thiocresol 
• 1772-03-8 D-(+)-galactosamine hydrochloride 
• 100-39-0 benzyl bromide 
• 949489-05-8 p-tolyl 3,4,6-tri-O-acetyl-2-amino-2-deoxy-1-thio-β-D-galactopyranoside 
• 533927-89-8 p-tolyl 3,4,6-tri-O-acetyl-2-deoxy-2-N-(2,2,2-trichloroethoxycarbonylamino)-1-thio-β-D-galactopyranoside 
• 917592-29-1 p-tolyl 2-O-benzoyl-3,4,6-tri-O-benzyl-1-thio-β-D-galactopyranoside 
• 949489-13-8 p-tolyl 3,4,6-tri-O-benzyl-1-thio-β-D-galactopyranoside 
• 897364-02-2 p-tolyl 2-O-acetyl-3,4,6-tri-O-benzyl-1-thio-β-D-galactopyranoside 
• 4163-60-4 β-D-galactose peracetate 

Downstream Products

• 949489-24-1 p-tolyl 3,4,6-tri-O-benzyl-β-D-galactopyranosyl-(1->3)-4,6-O-benzylidene-2-amino-2-deoxy-1-thio-β-D-galactopyranoside 
• 949489-20-7 p-tolyl 3,4,6-tri-O-benzyl-β-D-galactopyranosyl-(1->3)-4,6-O-benzylidene-2-(2,2,2-trichloroethoxycarbonylamino)-2-deoxy-1-thio-β-D-galactopyranoside 

Relevant academic research and scientific papers

Fast and low-cost purification strategy for oligosaccharide synthesis based on a hop-on/off carrier

A feasible and convenient strategy for oligosaccharide synthesis, which realizes reaction in solution while product purification occurs only by solid-liquid filtration, has been developed. By using a hop-on/off carrier (polytetrafluoroethylene particle), rapid synthesis of tumor-associated antigen Globo-H hexasaccharide has been successfully achieved within 5 steps in 48% overall yield without any intermediate purification by column chromatography. Also, global deprotection, including the cleavage of the tag, proceeded simultaneously only by one-step hydrogenolysis.

Synthesis and immunological evaluation ofN-acyl modified Globo H derivatives as anticancer vaccine candidates

Globo H is a tumor-associated carbohydrate antigen (TACA), which serves as a valuable target for antitumor vaccine or cancer immunotherapies. However, most TACAs are T-cell-independent, and they cannot induce powerful immune response due to their poor imm

Multi-component one-pot synthesis of the tumor-associated carbohydrate antigen globo-H based on preactivation of thioglycosyl donors

(Chemical Equation Presented) Two efficient routes for the rapid assembly of the tumor-associated carbohydrate antigen Globo-H hexasaccharide 2 by a preactivation based iterative one-pot strategy are reported. The first method involves the sequential coup