94961-24-7

Upstream product

• 199285-74-0 diethyl 2,6-dimethyl-4-(4-hydroxy-3-methoxyphenyl)pyridine-3,5-dicarboxylate 
• 77-78-1 dimethyl sulfate 
• 141-97-9 ethyl acetoacetate 
• 120-14-9 3,4-dimethoxy-benzaldehyde 
• 629649-41-8 4-(4-acetoxy-3-methoxy-phenyl)-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid diethyl ester 
• 856955-39-0 4-(4-acetoxy-3-methoxy-phenyl)-2,6-dimethyl-pyridine-3,5-dicarboxylic acid diethyl ester 
• 10354-31-1 4-(4-hydroxy-3-methoxy-phenyl)-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid diethyl ester 
• 10354-32-2 diethyl 4-(3,4-dimethoxyphenyl)-2,6-dimethyl-1,4-dihydropyridine 3,5-dicarboxylate 

Downstream Products

• 98918-02-6 4-(3,4-Dimethoxy-phenyl)-2-methyl-5-oxo-5,6-dihydro-[1,6]naphthyridine-3-carboxylic acid ethyl ester 

Relevant academic research and scientific papers

BIFC and QFC promoted rapid and cleaner aromatization of 1,4-dihydropyridines under solvent-free condition

(Chemical Equation Presented) This communication expresses aromatisation of 1,4-dihydropyridines to pyridine derivatives with the help of alumina supported benzimidazolium fluorochromate (BIFC) and quinolinium fluorochromate (QFC) as oxidants under solvent-free microwave irradiation. Moderate to excellent yield (80-98%) of pyridine derivatives were achieved by this methodology.

One-pot synthesis of 3-hydroxy-2-oxindole-pyridine hybrids via Hantzsch ester formation, oxidative aromatization and sp3 C–H functionalization using FeWO4 nanoparticles as recyclable heterogeneous catalyst

Synthesis of poly-substituted 3-hydroxy-2-oxindole-pyridine hybrids is reported via sp3 C–H bond functionalization as key steps using FeWO4 nanoparticles as reusable heterogeneous catalyst. Formation of Hantzsch ester (DHP) followed by aromatization, and sp3 C–H bond functionalization was achieved using FeWO4 nanoparticles (20 mol%) at 80 °C. Temperature dependent reactivity was observed for mono aldol (at 80 °C) and bis aldol (at 120 °C) products. The catalyst was regenerated and reused up to 6 cycles without losing catalytic activity. The FeWO4 nanoparticles were also used for oxidative aromatization of different DHP derivatives and for the sp3 C–H functionalization of 2-methyl pyridine.

For 1, 4 - dihydro pyridine compound to prepare the corresponding pyridine compound (by machine translation)

The invention discloses a method for the 1, 4 - dihydro pyridine compound to prepare the corresponding pyridine compound. The method of the invention is: will be 1, 4 - dihydro pyridine compound, eosin Y of the four n-butyl ammonium salt, potassium carbonate is added to the organic solvent with the water in the mixed solvent of stirring and mixing, inject the air in visible light irradiation under the conditions of reaction, to be after the reaction, by adding ethyl acetate, respectively water, saturated ammonium chloride washing, removal of inorganic alkali and adjust the system to subacid, in the organic phase by adding a small amount of activated carbon to remove the pigment, then dried with anhydrous sodium sulfate, turns on lathe does, recrystallize and obtain the corresponding pyridine compound. The method of the invention compared with the prior art has to oxygen in air as the oxidizing agent, is cheap and easy to get; to sunlight as the energy source, so that the industrial production more favorable; catalytic amount of the use of non-metal catalyst, reduces the cost of synthesizing, avoiding the noble metal in the accumulation of drug in the synthesis. (by machine translation)

Metal-free-mediated oxidation aromatization of 1,4-dihydropyridines to pyridines using visible light and air

A metal-free and environmentally friendly aerobic aromatization photosensitized by organic dye eosin Y bis(tetrabutyl ammonium salt) (TBA-eosinY) has been developed. With the aid of K2CO3, the aerobic catalytic system converts 1,4-dihydropyridines to their corresponding pyridine derivatives efficiently under visible light irradiation (λ=450 nm) at room temperature.

Oxidative aromatization of Hantzsch 1,4-dihydropyridines by cupric bromide under mild heterogeneous condition

A mild heterogeneous oxidizing agent, cupric bromide has been utilized for the oxidative aromatization of Hantzsch 1,4-dihydropyridines to the corresponding pyridine derivatives in excellent yields with the isolation of products by simple work-up procedur

Iodobenzene diacetate (IBD) catalyzed an quick oxidative aromatization of Hantzsch-1,4-dihydropyridines to pyridines under ultrasonic irradiation

This project was undertaken to demonstrate the potential of iodobenzene diacetate for the oxidative aromatization of Hantzch-1,4-dihydropyridines under ultrasonic irradiation. All reactions were carried out under ultrasonic irradiation and results were co

An expeditious oxidative aromatization of hantzsch 1,4-dihydropyridines to pyridines using cetyltrimethylammonium peroxodisulfate: A phase transferring oxidant

A new approach to the use of potassium peroxodisulphate as an oxidizing reagent is proposed and applied to the case of oxidative aromatization of 1, 4-dihydropyridines with cetyltrimethylammonium peroxodisulfate, a phase transfer oxidant. We demonstrate h

A novel, facile, simple and convenient oxidative aromatization of Hantzsch 1,4-dihydropyridines to pyridines using polymeric iodosobenzene with KBr

An easy, safe, effective and handy method for oxidative aromatization of Hantzsch 1,4-dihydropyridines catalyzed by hypervalent iodine (iodosobenzene) and potassium bromide to corresponding pyridine derivatives in high-yields and within short span of time was described. Dealkylation in case of 4-n-alkyl substituted 1,4-dihydropyridines was not obtained.

Multicomponent domino cyclization-oxidative aromatization on a bifunctional Pd/C/K-10 catalyst: An environmentally benign approach toward the synthesis of pyridines

A one-pot synthesis of substituted pyridines via a domino cyclization-oxidative aromatization (dehydrogenation) approach is described. The process is based on the use of a new bifunctional noble metal-solid acid catalyst, Pd/C/K-10 montmorillonite and mic

Iodoxybenzoic acid (IBX): An efficient and novel oxidizing agent for the aromatization of 1,4-dihydropyridines

Hantzsch 1,4-dihydropyridines undergo smooth aromatization catalyzed by iodoxybenzoic acid (IBX) to afford the corresponding pyridine derivatives in high yields. All the reactions were carried out in DMSO solvent at 80-85 °C for a period of two to four ho