10354-32-2

Basic information

• Product Name: diethyl 4-(3,4-dimethoxyphenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
• Synonyms: 3,5-Pyridinedicarboxylic acid, 4-(3,4-dimethoxyphenyl)-1,4-dihydro-2,6-dimethyl-, diethyl ester; Diethyl 4-(3,4-dimethoxyphenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
• CAS NO: 10354-32-2
• Molecular Formula: C₂₁H₂₇NO₆
• Molecular Weight: 389.4422
• Mol File: 10354-32-2.mol
• Article Data: 32

Chemical Properties

• Boiling Point: 499.8°C at 760 mmHg
• Flash Point: 256°C
• Density: 1.14g/cm³
• Vapor Pressure: 4.03E-10mmHg at 25°C
• Refractive Index: 1.521
• CAS DataBase Reference: diethyl 4-(3,4-dimethoxyphenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: diethyl 4-(3,4-dimethoxyphenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate(10354-32-2)
• EPA Substance Registry System: diethyl 4-(3,4-dimethoxyphenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate(10354-32-2)

Safety Data

• Hazardous Substances Data: 10354-32-2(Hazardous Substances Data)

Upstream product

• 621-59-0 isovanillin 
• 506-87-6 ammonium carbonate 
• 141-97-9 ethyl acetoacetate 
• 120-14-9 3,4-dimethoxy-benzaldehyde 
• 631-61-8 ammonium acetate 
• 121-33-5 vanillin 
• 10354-31-1 4-(4-hydroxy-3-methoxy-phenyl)-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid diethyl ester 
• 77-78-1 dimethyl sulfate 
• 320741-61-5 4-(3-hydroxy-4-methoxyphenyl)-1,4-dihydro-2,6-dimethylpyridine-3,5-dicarboxylic acid diethyl ester 

Downstream Products

• 94961-24-7 diethyl 2,6-dimethyl-4-(3,4-dimethoxyphenyl)pyridine-3,5-dicarboxylate 

Relevant articles and documents

A magnetic nanoparticle supported Ni2+-containing ionic liquid as an efficient nanocatalyst for the synthesis of Hantzsch 1,4-dihydropyridines in a solvent-free dry-system

The highly efficient synthesis of 1,4-dihydropyridines (1,4-DHPs) is reported via the condensation reaction of aldehydes, ethyl acetoacetate and ammonium acetate, using an environmentally benign Ni2+-containing 1-methyl-3-(3-trimethoxysilylprop

One-pot, solvent free synthesis of hantzsch 1, 4-dihydropyridines using β-cyclodextrin as a supramolecular catalyst

A novel, solvent free and efficient one pot synthesis of 1, 4-dihydropyridine derivatives was achieved in good yields via three component reaction of aldehydes, ethyl acetoacetate and ammonium acetate using inexpensive β- cyclodextrin as a supramolecular catalyst. The catalyst can be recovered and reused without loss of activity.

Dual solvent-catalyst role of deep eutectic solvents in Hantzsch dihydropyridine synthesis

Deep eutectic solvents are a class of new generation green solvents formed from two or more components, which furnish a new homogeneous liquid phase with lower melting point than the individual components. Here, for the first time, dual role of DES as cat

Search for Antimicrobial Activity Among Fifty-Two Natural and Synthetic Compounds Identifies Anthraquinone and Polyacetylene Classes That Inhibit Mycobacterium tuberculosis

Drug-resistant tuberculosis threatens to undermine global control programs by limiting treatment options. New antimicrobial drugs are required, derived from new chemical classes. Natural products offer extensive chemical diversity and inspiration for synthetic chemistry. Here, we isolate, synthesize and test a library of 52 natural and synthetic compounds for activity against Mycobacterium tuberculosis. We identify seven compounds as antimycobacterial, including the natural products isobavachalcone and isoneorautenol, and a synthetic chromene. The plant-derived secondary metabolite damnacanthal was the most active compound with the lowest minimum inhibitory concentration of 13.07 μg/mL and a favorable selectivity index value. Three synthetic polyacetylene compounds demonstrated antimycobacterial activity, with the lowest MIC of 17.88 μg/mL. These results suggest new avenues for drug discovery, expanding antimicrobial compound chemistries to novel anthraquinone and polyacetylene scaffolds in the search for new drugs to treat drug-resistant bacterial diseases.

Diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate derivative for inducing cell apoptosis, a method for producing the same, and an anticancer drug containing the same

The present invention relates to a diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate derivative which induces cell apoptosis, a method of manufacturing the same, and an anti-cancer drug containing the same. A compound represented by chemical form