diethyl 2,6-dimethyl-4-(3,4-dimethoxyphenyl)pyridine-3,5-dicarboxylate

Base Information

• Chemical Name: diethyl 2,6-dimethyl-4-(3,4-dimethoxyphenyl)pyridine-3,5-dicarboxylate
• CAS No.: 94961-24-7
• Molecular Formula: C₂₁H₂₅NO₆
• Molecular Weight: 387.433
• Mol file: 94961-24-7.mol

Synonyms:diethyl 2,6-dimethyl-4-(3,4-dimethoxyphenyl)pyridine-3,5-dicarboxylate

Chemical Property of diethyl 2,6-dimethyl-4-(3,4-dimethoxyphenyl)pyridine-3,5-dicarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of diethyl 2,6-dimethyl-4-(3,4-dimethoxyphenyl)pyridine-3,5-dicarboxylate

There total 6 articles about diethyl 2,6-dimethyl-4-(3,4-dimethoxyphenyl)pyridine-3,5-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

diethyl 4-(3,4-dimethoxyphenyl)-2,6-dimethyl-1,4-dihydropyridine 3,5-dicarboxylate (10354-32-2) → diethyl 2,6-dimethyl-4-(3,4-dimethoxyphenyl)pyridine-3,5-dicarboxylate (94961-24-7)

Guidance literature:

With alumina supported benzimidazolium fluorochromate; for 0.05h; microwave irradiation;

DOI:10.1002/jhet.5570440438

Reference yield: 90.0%

ethyl acetoacetate (141-97-9) + 3,4-dimethoxy-benzaldehyde (120-14-9) → diethyl 2,6-dimethyl-4-(3,4-dimethoxyphenyl)pyridine-3,5-dicarboxylate (94961-24-7)

Guidance literature:

With iron tungstate; ammonium acetate; In acetic acid; at 80 ℃; for 2h; Green chemistry;

DOI:10.1016/j.catcom.2017.09.027

Reference yield:

4-(4-hydroxy-3-methoxy-phenyl)-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid diethyl ester (10354-31-1) → diethyl 2,6-dimethyl-4-(3,4-dimethoxyphenyl)pyridine-3,5-dicarboxylate (94961-24-7)

Guidance literature:

Multi-step reaction with 4 steps

2: acetic acid; CrO₃

3: ethanolic KOH

4: aqueous KOH

With chromium(VI) oxide; potassium hydroxide; acetic acid;

upstream raw materials:

diethyl 2,6-dimethyl-4-(4-hydroxy-3-methoxyphenyl)pyridine-3,5-dicarboxylate

dimethyl sulfate

diethyl 4-(3,4-dimethoxyphenyl)-2,6-dimethyl-1,4-dihydropyridine 3,5-dicarboxylate

4-(4-hydroxy-3-methoxy-phenyl)-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid diethyl ester

Downstream raw materials:

4-(3,4-Dimethoxy-phenyl)-2-methyl-5-oxo-5,6-dihydro-[1,6]naphthyridine-3-carboxylic acid ethyl ester