94988-86-0Relevant academic research and scientific papers
Single-step synthesis of substituted 7-aminopyrano[2,3-d]pyrimidines
Shestopalov,Rodinovskaya,Shestopalov,Litvinov
, p. 2342 - 2344 (2004)
A single-step method for the synthesis of substituted 7-aminopyrano[2,3-d] pyrimidines was developed. The method involves a three-component reaction of barbituric acid or 4,6-dihydroxypyrimidine with aromatic aldehydes and malononitrile in DMF in the pres
Synthesis and catalytic activity of a novel ionic liquid-functionalized metal–organic framework
Sadjadi, Samahe,Koohestani, Fatemeh
, p. 291 - 306 (2021/09/07)
In this research, a new heterogeneous catalyst is fabricated through covalent modification of iron-based metal–organic framework with ionic liquid. In more detail, using 2-aminoterephthalic acid and iron (III) chloride hexahydrate, amino-functionalized me
WELPSA: A natural catalyst of alkali and alkaline earth metals for the facile synthesis of tetrahydrobenzo[b]pyrans and pyrano[2,3-d]pyrimidinones as inhibitors of SARS-CoV-2
Nesaragi, Aravind R.,Kamble, Ravindra R.,Hoolageri, Swati R.,Mavazzan, Ahmedraza,Madar, Suresh F.,Anand, Ashish,Joshi, Shrinivas D.
, (2021/10/19)
Since 2019, the infection of SARS-CoV-2 has been spreading worldwide and caused potentially lethal health problems. In view of this, the present study explores the most commodious and environmentally benign synthetic protocol for the synthesis of tetrahyd
Polyionic liquid decorated chitosan beads as versatile metal-free catalysts for catalyzing chemical reactions in aqueous media
Koohestani, Fatemeh,Sadjadi, Samahe
, (2021/04/19)
A new strategy is presented for enhancing the catalytic activity of cross-linked chitosan beads. More precisely, chitosan beads were cross linked with glutaraldehyde and then, vinyl functionalized. In the next step, the vinyl-functionalized beads were pol
Efficient biogenesis of Cu2O nanoparticles using extract of Camellia sinensis leaf: Evaluation of catalytic, cytotoxicity, antioxidant, and anti-human ovarian cancer properties
Dou, Lei,Zhang, Xinxin,Zangeneh, Mohammad Mahdi,Zhang, Yi
, (2020/11/27)
At the moment, metallic nanoparticles especially copper nanoparticles are administrated for the cure of different disorders, such as tumor and cancer. In recent years, many chemotherapeutic supplements have been formulated by copper nanoparticles. In the
New advances in catalytic performance of erbium-folic acid-coated CoFe2O4 complexes for green one-pot three-component synthesis of pyrano[2,3-d]pyrimidinone and dihydropyrano[3,2-c]chromenes compounds in water
Sorkhabi, Serve,Mozafari, Roya,Ghadermazi, Mohammad
, (2021/04/30)
In the current research, much attention is paid to heterogenized nanostructure. Herein, we report the green synthesis magnetic nanoparticles (MNPs) of cobalt ferrite by the immobilization of erbium (Er) coated with folic acid (FA) which show effective cat
Synthesis, biological activity and POM/DFT/docking analyses of annulated pyrano[2,3-d]pyrimidine derivatives: Identification of antibacterial and antitumor pharmacophore sites
Bhat, Ajmal R.,Dongre, Rajendra S.,Almalki, Faisal A.,Berredjem, Malika,Aissaoui, Mohamed,Touzani, Rachid,Hadda, Taibi Ben,Akhter, Mohammad S.
, (2020/12/07)
New annulated pyrano[2,3-d]pyrimidine derivatives were synthesized with hydroxyl, methoxy, bromine, nitrile and nitro substituents on its skeleton. The correlated electronic effect of substituents on the magnitude of antibacterial activity was noted. The
Three-component synthesis of 4H-pyran scaffolds accelerated by a gabapentin-based natural deep eutectic solvent
Alipour Khoshdel, Meysam,Shirini, Farhad,Nikoo Langarudi, Mohaddeseh Safarpoor,Zabihzadeh, Mehdi,Biglari, Mohammad
, p. 3138 - 3149 (2021/02/26)
The development of environmentally benign synthetic protocols has attracted increasing attention in recent organic syntheses. As a part of this concept, our group synthesized a new natural deep eutectic solvent (NADES) by using gabapentin and choline chlo
4,4'-trimethylenedipiperidine as a nitrogen heterocycle solvent and/or catalyst: Liquid phase tandem Knoevenagel-Michael condensation
Zaharani, Lia,Ghaffari Khaligh, Nader,Gorjian, Hayede,Rafie Johan, Mohd
, p. 261 - 268 (2021/03/16)
Liquid phase tandem Knoevenagel-Michael condensation of various aromatic and heteroaromatic aldehydes with barbituric acid or 2-thiobarbituric acid and malononitrile was studied in a one-pot three-component reaction. For the first time, TMDP was employed as a safe and efficient solvent and/or catalyst in the liquid and aqueous ethanol medium, respectively, for the practical and eco-friendly Knoevenagel-Michael condensation. The reactions were carried out by using greener procedures, including a) the use of TMDP as an N-heterocycle organocatalyst in a green medium including water and ethanol (1:1 v/v) at reflux temperature, and b) the use of TMDP as a dual solvent-catalyst at 65 °C in the absence of any solvent. High to excellent yields of the desired pyrano[2,3-d] pyrimidinones were obtained under the two earlier mentioned conditions. The current methodologies have advantages, including (a) avoiding hazardous, toxic, volatile, and flammable materials and solvents, (b) avoiding tedious processes, harsh conditions, and multiple steps for the preparation of catalysts, (c) using a less toxic and noncorrosive catalyst, (d) minimizing hazardous waste generation and simple workup process, and (e) high recyclability of TMDP. Another important result of this work is that the TMDP can be a promising alternative for toxic, volatile, and flammable base reagents such as piperidine and triethylamine in liquid phase organic syntheses owing to its unique properties such as being less toxic, nonflammable, and nonvolatile, and having a low melting point, broad liquid range temperature, high thermal stability, and safe handling and storage.
Convenient and fast synthesis of various chromene pharmaceuticals assisted by highly porous volcanic micro-powder with nanoscale diameter porosity
Maleki, Ali,Valadi, Kobra,Gharibi, Saideh,Taheri-Ledari, Reza
, p. 4113 - 4128 (2020/07/06)
Herein, a volcanic-based mesoporous catalytic system is precisely characterized by various analytical methods and suitably used for facilitating the organic synthesis reactions. Briefly, high reaction yield (99percent) has been obtained in short reaction
