94992-56-0

Usage

Usage

Primarily used as a reagent in organic synthesis and as a solvent in various chemical processes.

Industry application

Commonly used in the pharmaceutical industry for the synthesis of drug intermediates and in the manufacturing of specialty chemicals.

Reactivity

High reactivity, can be used as a catalyst in certain reactions.

Physical state

Colorless, volatile liquid.

Odor

Mild, sweet odor.

Stability

Relatively stable under normal conditions.

Safety precautions

Should be handled with care and stored in a cool, dry place away from direct sunlight and heat sources.

Upstream product

• 32233-43-5 2-[(S)-2,2-dimethyl-1,3-dioxolan-4-yl]ethanol 
• 98-59-9 p-toluenesulfonyl chloride 
• 4124-41-8 p-toluenesulfonylanhydride 
• 95598-71-3 (S)-4-(2-benzoyloxy)ethyl-2,2-dimethyl-1,3-dioxolane 
• 95422-24-5 methyl (3S)-3,4-O-isopropylidene-3,4-dihydroxybutanoate 

Downstream Products

• 67987-67-1 (4S)-4-(2-iodoethyl)-2,2-dimethyl-1,3-dioxolane 
• 94944-62-4 (S)-4,5-O-isopropylidene-4,5-dihydroxypentanenitrile 
• 569675-07-6 5-cyano-6-cyclohexyl-{2-[(S)-2,2-dimethyl-1,3-dioxolan-4-yl]ethyl}uracil 
• 114884-40-1 (S)-3,4-O-isopropylidene-3,4-dihydroxybutyltriphenylphosphonium iodide 
• 94944-64-6 (S)-N-<(benzyloxy)carbonyl>-1,2-O-isopropylidene-5-amino-1,2-pentanediol 
• 94944-63-5 (S)-1,2-O-isopropylidene-5-amino-1,2-pentanediol 

Relevant academic research and scientific papers

6,7-DIHYDRO-5H-PYRIDO[2,3-C]PYRIDAZINE DERIVATIVES AND RELATED COMPOUNDS AS BCL-XL PROTEIN INHIBITORS AND PRO-APOPTOTIC AGENTS FOR TREATING CANCER

The present invention discloses 6,7-dihydro-5H-pyrido[2,3- c]pyridazine, 1,2,3,4-tetrahydroquinoline, 1H-indole, 3,4- dihydro-2H-1,4-benzoxazine, 1H-pyrrolo[2,3-b]pyridin-1-yl, 7H- pyrrolo[2,3-c]pyridazine, 5H,6H,7H,8H,9H-pyridazino[3,4-b]azepine derivatives and related compounds of formula (I) as Bcl-xL protein inhibitors for use as pro-apoptotic agents for treating cancer, autoimmune diseases or immune system diseases. Formula (I). The description discloses the preparation of exemplary compounds (e.g. pages 113 to 354 examples 1 to 221) as well as pharmacological studies with relevant data (e.g. pages 355 to 367; examples A to E; tables 1 to 5). Exemplary compounds are e.g. 2-{6-[(1,3-benzothiazol-2-yl) amino]-1,2,3,4-tetrahydroquinolin-1-yl}-1,3-thiazole-4-carboxylic acid (example 1) or e.g. 3-{1-[(adamantan-1-yl)methyl]-5- methyl-1H-pyrazol-4-yl}-6-{3-[(1,3-benzothiazol-2-yl)amino]-4- methyl-5H,6H,7H,8H-pyrido[2,3-c]pyridazin-8-yl]pyridine-2-carboxylic acid (example 24).

Synthesis and incorporation of a simple acyclic furan containing phosphoramidite

A novel furan containing phosphoramidite was synthesized and incorporated into model oligonucleotides. This glycol nucleic acid based building block contains a furan unit substituting the natural base, and can be used for post synthetic oligonucleotide mo

Heterocyclic compound, composition and method for inhibiting adenosine deaminase

Heterocyclic compounds of the following formula: wherein B is ?[wherein R1is hydrogen or lower alkyl; R2is hydrogen or lower alkyl; and X is hydrogen or hydroxy protective group], lower alkanoyl or hydroxyimino(lower)alkyl A is lower

SYNTHESES OF 1-OXAQUINOLIZIDINES VIA REDUCTIVE CYCLIZATION OF HYDROXY-LACTAMS

The synthesis of the 1-oxaquinolizidine moiety of xestospongin A via reductive iminium ion formation from a lactam is described. Key Words: 1-oxaquinolizidine; iminium ion; "ate" complex from DIBAL and n-BuLi; xestospongin A; iminium ion-enamine tautomeri

Synthesis of 2-hydroxymethyl-1-oxaquinolizidine

The synthesis of 2-hydroxymethyl-1-oxaquinolizidine from L-malic acid and 1,5 pentanediol, is reported.

Synthesis of the Oviposition-Deterring Pheromone of Rhagoletis cerasi L.

The oviposition-deterring pheromone of Rhagoletis cerasi L. (-)-(8R,15R)-1 and a mixture of the two compounds (-)-(8R and 8S,15R)-1 have been synthesized.In the presence of the 1,5-cyclooctadiene-CuCl complex as a catalyst the Grignard reagent of (-)-(R)-

A new practical enantiospecific synthesis of unlabelled and tritium labelled 12-HETEs

The oxidative metabolism of arachidonic acid AA is known to yield a variety of biologically active substances.Among them, both enantiomers of 12-hydroxyeicosatetraenoic acid (12-HETE) have been the subject of much interest.In order to extend their biologi

(R)- and (S)-4-Methylaminomethyl-2,3,4,9-tetrahydrothiopyranoindole: Synthesis, Absolute Configuration, Conformation, and Analgesic Activity

(R)- and (S)-4-Methylaminomethyl-2,3,4,9-tetrahydrothiopyranoindole (2) have been synthesized and their conformation studied. (RS)-(2) has been found to be a potent non-narcotic analgesic agent.The crucial step was regio- and stereo-specific cycliz

SYNTHESIS OF THE ENANTIOMERS OF 1,7-DIOXASPIROUNDECANE, 4-HYDROXY-1,7-DIOXASPIROUNDECANE AND 3-HYDROXY-1,7-DIOXASPIROUNDECANE, THE COMPONENTS OF THE OLIVE FRUIT FLY PHEROMONE

All of the enantiomers of the title compounds, the components of the pheromone of the olive fruit fly (Dacus oleae Gmelin), were synthesized from (S)-malic acid.