950188-80-4

Upstream product

• 75-77-4 chloro-trimethyl-silane 
• 22062-53-9 5-fluoro-2-methylbenzaldehyde 
• 75-36-5 acetyl chloride 

Downstream Products

• 1239779-17-9 racemic (2'R,3R,4'S)-4'-[5-chloro-2-(2-methanesulfonylamino-1,1-methyl-2-oxo-ethoxy)pyridin-3-yl]-6-chloro-2'-(5-fluoro-2-methyl-phenyl)spiro[3H-indole-3,3'-piperidine]-2,6'(1H)-dione 
• 1239779-16-8 racemic (2'S,3S,4'R)-4'-[5-chloro-2-(2-methanesulfonylamino-1,1-methyl-2-oxo-ethoxy)pyridin-3-yl]-6-chloro-2'-(5-fluoro-2-methyl-phenyl)spiro[3H-indole-3,3'-piperidine]-2,6'(1H)-dione 
• 1239779-14-6 (2'R,3R,4'S)-6-chloro-4'-[5-chloro-2-(1-hydroxycarbonyl-1-methyl-ethoxy)pyridin-3-yl]-2'-(5-fluoro-2-methyl-phenyl)spiro[3H-indole-3,3'-piperidine]-2,6'(1H)-dione 
• 1239779-13-5 (2'S,3S,4'R)-6-chloro-4'-[5-chloro-2-(1-hydroxycarbonyl-1-methyl-ethoxy)pyridin-3-yl]-2'-(5-fluoro-2-methyl-phenyl)spiro[3H-indole-3,3'-piperidine]-2,6'(1H)-dione 

Relevant academic research and scientific papers

SPIROINDOLINONE DERIVATIVE PRODRUGS

There are provided compounds of the formula and pharmaceutically acceptable salts and esters and enantiomers thereof wherein X, Y, V, R1, R2 and R are as described herein. The compounds have utility as antiproliferative agents, especially, as anticancer agents.

3,3'-SPIROINDOLINONE DERIVATIVES AND THEIR USE FOR CANCER

There are provided compounds of the formula (I) or a pharmaceutically acceptable salt or ester thereof wherein X, Y, W, W?,V, V?, V", R1, R2 and R3 are as herein described. The compounds have utility as antiproliferative agents, especially, as anticancer

SPIROINDOLINONE PYRIDINE DERIVATIVES

There are provided compounds of the formula or a pharmaceutically acceptable salt, ester or enantiomer thereof wherein W, X, Y, V, R1 and R2 are as described herein. The compounds have utility as antiproliferative agents, especially,

Spiroindolinone Derivatives

There are provided compounds of the formula and pharmaceutically acceptable salts and esters and enantiomers thereof wherein W, X, X′, Y, V, V′, A, B and R are as described herein. The compounds have utility as antiproliferative agents, especially, as anticancer agents.

SPIROINDOLINONE DERIVATIVES

There are provided spiroindolinone derivatives of the formula and pharmaceutically acceptable salts and esters thereof wherein R1, R2, R3, R4 and R are as herein described. The compounds exhibit anticancer activity.