95019-16-2

Usage

Uses

Used in Neuroscience Research:
4-Methyl-1,2,3,6-tetrahydropyridine hydrochloride is used as a neurotoxin in laboratory settings for [application reason] inducing Parkinson's disease-like symptoms in animal models. This allows researchers to study the underlying mechanisms of the disease and to evaluate the efficacy of potential therapeutic agents.
Used in Neuropathology Studies:
In the field of neuropathology, 4-Methyl-1,2,3,6-tetrahydropyridine hydrochloride is used as a tool to investigate the selective destruction of dopaminergic neurons, which is a hallmark of Parkinson's disease. This helps in understanding the progression of neurodegeneration and the development of targeted therapies.
Used in Drug Development:
4-Methyl-1,2,3,6-tetrahydropyridine hydrochloride is utilized in drug development as a means to test potential therapeutic agents for Parkinson's disease. By observing the effects of these agents on the neurotoxin-induced symptoms in animal models, researchers can assess their potential to alleviate or reverse the disease's symptoms and progression.
Used in Mechanistic Studies of Neurodegeneration:
In the study of neurodegeneration, 4-Methyl-1,2,3,6-tetrahydropyridine hydrochloride is employed to explore the mechanisms that lead to the death of dopaminergic neurons. This knowledge is crucial for developing strategies to prevent or slow down the neurodegenerative process in Parkinson's disease and other related disorders.

Upstream product

• 112423-96-8 N-<(R)-2-Hydroxy-1-methoxycarbonylethyl>-4-methyl-3,4-didehydropiperidin 
• 57042-58-7 1-benzyl-1-bromo-4-methylpyridinium bromide 
• 108-89-4 picoline 
• 32018-56-7 1-benzyl-4-methyl-1 ,2,3,6-tetrahydropyridine 
• 78-79-5 isoprene 
• 50-00-0 formaldehyd 

Relevant academic research and scientific papers

Ytterbium(III) trifluoromethanesulfonate catalyzed solid phase aza Diels-Alder reaction and subsequent facile adduct release

Ytterbium(III) trifluoromethanesulfonate has been demonstrated to catalyze the solid phase aza Diels-Alder reaction of an aldehyde, a diene, and immobilized benzylamine. The [4+2] adducts were cleaved from solid support efficiently using a 'trace-less' re

Potent and Selective Tetrahydroisoquinoline Kappa Opioid Receptor Antagonists of Lead Compound (3 R)-7-Hydroxy- N-[(1 S)-2-methyl-1-(piperidin-1-ylmethyl)propyl]-1,2,3,4-tetrahydroisoquinoline-3-carboxamide (PDTic)

Past studies have shown that it has been difficult to discover and develop potent and selective κ opioid receptor antagonists, particularly compounds having potential for clinical development. In this study, we present a structure-activity relationship (SAR) study of a recently discovered new class of tetrahydroisoquinoline κ opioid receptor antagonists which led to (3R)-7-hydroxy-N-{(1S)-2-methyl-1-[(-4-methylpiperidine-1-yl)methyl]propyl}-1,2,3,4-tetrahydroisoquinoline-3-carboxamide (12) (4-Me-PDTic). Compound 12 had a Ke = 0.37 nM in a [35S]GTPγS binding assay and was 645- and >8100-fold selective for the κ relative to the μ and δ opioid receptors, respectively. Calculated log BB and CNS (central nervous system) multiparameter optimization (MPO) and low molecular weight values all predict that 12 will penetrate the brain, and pharmacokinetic studies in rats show that 12 does indeed penetrate the brain.

2-SULFONYLAMINO-4-HETEROARYL BUTYRAMIDE ANTAGONISTS OF CCR10

This invention relates to a compound of formula (I) and the pharmaceutically acceptable salts thereof wherein R1, R2, R4. Ar and Het are as defined herein. The invention also relates to methods of using the compound of for

Asymmetric Hetero Diels-Alder Reactions in Aqueous Solution Using Amino Acid Esters as Chiral Auxiliaries

(R)- and (S)-amino acid methyl ester hydrochlorides form with formaldehyde in THF/water mixtures iminium ions, which react already at 0 deg C as electron-deficient dienophiles in hetero Diels-Alder reactions with cyclopentadiene, cyclohexadiene, and open-