32018-56-7

Usage

Uses

Used in Pharmaceutical Research:
1-Benzyl-4-methyl-1,2,3,6-tetrahydro-pyridine is used as a research compound for studying the pathophysiology of Parkinson's disease. Its application is crucial in understanding the neurodegenerative processes and the effects on the dopaminergic system, which is primarily affected in Parkinson's patients.
Used in Toxicological Studies:
MPTP is utilized in toxicological research to investigate the mechanisms of neurotoxicity and to develop methods for detecting and mitigating the effects of similar toxic compounds on the human brain and nervous system.
Used in Drug Development:
In the field of drug development, 1-Benzyl-4-methyl-1,2,3,6-tetrahydro-pyridine is used as a model compound to screen for potential neuroprotective agents and to evaluate the efficacy of new treatments aimed at combating the symptoms and progression of Parkinson's disease.
Used in Neurodegenerative Disease Research:
MPTP is employed in the broader context of neurodegenerative disease research to explore common pathways and mechanisms that may be targeted for therapeutic intervention across different conditions, thereby contributing to the development of a more comprehensive understanding of such diseases.

InChI:InChI=1/C13H17N/c1-12-7-9-14(10-8-12)11-13-5-3-2-4-6-13/h2-7H,8-11H2,1H3

Upstream product

• 57042-58-7 1-benzyl-1-bromo-4-methylpyridinium bromide 
• 127073-72-7 [Benzyl-(3-methyl-but-3-enyl)-amino]-acetonitrile 
• 23662-66-0 1-benzyl-4-methylpyridinium chloride 
• 108-89-4 picoline 
• 100-39-0 benzyl bromide 
• 3970-66-9 1-benzyl-4-methyl-piperidin-4-ol 
• 1198423-01-6 N-benzyl-2-methyl-2-vinylazetidine 
• 20012-94-6 4-methyl-4-vinylazetidin-2-one 
• 100-44-7 benzyl chloride 
• 3612-20-2 1-phenylmethyl-4-piperidone 

Downstream Products

• 384338-20-9 trans-(RS)-4-methyl-1-(phenylmethyl)-3-piperidinol 
• 694-50-8 4-methyl-1,2,3,6-tetrahydropyridine 
• 103-29-7 1,1'-(1,2-ethanediyl)bisbenzene 
• 89873-54-1 1-Benzyl-4-methyl-3,6-dihydro-2H-pyridine 1-oxide 
• 384338-20-9 (rac, trans)-1-benzyl-4-methyl-piperidin-3-ol 
• 660403-89-4 1-benzyl-4-methyl-3,4-piperidinediol 
• 660403-89-4 (3R,4R)-1-Benzyl-4-methyl-piperidine-3,4-diol 
• 866929-74-0 (3R,4S)-1-benzyl-4-methyl-piperidine-3,4-diol 
• 95019-16-2 4-methyl-1,2,3,6-tetrahydropyridine hydrochloride 
• 384338-21-0 N-benzyl-3-hydroxy-4-methylpiperidinium toluene-4-sulfonate 
• 32018-96-5 1-benzyl-4-methyl-piperidin-3-one 
• 1548270-23-0 1-benzyl-4-methyl-3-(benzyl(methyl)amino)piperidin-4-ol 
• 1548270-31-0 1-benzyl-3-bromo-4-methylpiperidin-4-ol 
• 1548270-41-2 C₁₄H₂₀N₂ 

Relevant academic research and scientific papers

COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF PARASITIC DISEASES

The present invention provides a compound of formula (Ia) or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the invention, solid forms, combinations of pharmacologically active agents, pharmaceutical compositions and methods of using such compounds and solid forms thereof to treat or prevent parasitic diseases, for example malaria.

Metal-free reduction of unsaturated carbonyls, quinones, and pyridinium salts with tetrahydroxydiboron/water

A series of unsaturated carbonyls, quinones, and pyridinium salts have been effectively reduced to the corresponding saturated carbonyls, dihydroxybenzenes, and hydropyridines in moderate to high yields with tetrahydroxydiboron/water as a mild, convenient, and metal-free reduction system. Deuterium-labeling experiments have revealed this protocol to be an exclusive transfer hydrogenation process from water. This journal is

TRICYCLIC DEGRADERS OF IKAROS AND AIOLOS

Tricyclic cereblon binders for the degradation of Ikaros or Aiolos by the ubiquitin proteasome pathway for therapeutic applications are described.

CEREBLON BINDERS FOR THE DEGRADATION OF IKAROS

The present invention provides cereblon binders for the degradation of Ikaros or Aiolos by the ubiquitin proteasome pathway along with their use in therapeutic applications as described herein.

N-benzyl-tetrahydropyridine compound and preparation method thereof

The invention provides an N-benzyl-tetrahydropyridine compound and a preparation method thereof, and the preparation method comprises the following steps: S1, adding benzyl bromide into a pyridine compound to carry out nucleophilic substitution reaction t

A comparison between KbH4 and NaBH4 in their reduction of pyridinium salts

This paper compares potassium borohydride and sodium borohydride in the reduction of pyridinium salts to tetrahydropyridines. The results indicate that potassium borohydride is more suitable for this reaction with low costs, mild reaction conditions and i

Potent and Selective Tetrahydroisoquinoline Kappa Opioid Receptor Antagonists of Lead Compound (3 R)-7-Hydroxy- N-[(1 S)-2-methyl-1-(piperidin-1-ylmethyl)propyl]-1,2,3,4-tetrahydroisoquinoline-3-carboxamide (PDTic)

Past studies have shown that it has been difficult to discover and develop potent and selective κ opioid receptor antagonists, particularly compounds having potential for clinical development. In this study, we present a structure-activity relationship (SAR) study of a recently discovered new class of tetrahydroisoquinoline κ opioid receptor antagonists which led to (3R)-7-hydroxy-N-{(1S)-2-methyl-1-[(-4-methylpiperidine-1-yl)methyl]propyl}-1,2,3,4-tetrahydroisoquinoline-3-carboxamide (12) (4-Me-PDTic). Compound 12 had a Ke = 0.37 nM in a [35S]GTPγS binding assay and was 645- and >8100-fold selective for the κ relative to the μ and δ opioid receptors, respectively. Calculated log BB and CNS (central nervous system) multiparameter optimization (MPO) and low molecular weight values all predict that 12 will penetrate the brain, and pharmacokinetic studies in rats show that 12 does indeed penetrate the brain.

A supporting france for cloth as the starting material of the preparation method (by machine translation)

The invention discloses a method for supporting france for cloth starting material N - ((3 R, 4 R) - 4 - methyl - 1 - benzyl - 3 - piperidinyl) - N - methyl - 7 - paratoluene sulfonyl - 7 H - pyrrolo [2, 3 - D] pyrimidine - 4 - amine (I) synthetic method, specific steps are as follows: to 4 - methyl pyridine as the starting material, with the benzyl chloride undergo nucleophilic substitution by the 4 - methyl - 1 - phenylmethyl - pyridine hydrochloride, under the action of the sodium borohydride reduction reaction, borohydrite - oxidation reaction, hydroxy oxidation, the introduction of the reductive amination of the stereo selectivity of the two chiral center, through a readily available and inexpensive chiral acid (L - DTTA) splitting, to obtain optically pure intermediates (3 R, 4 R) - (1 - benzyl - 4 - methyl - piperidin - 3 - yl) - methylamine, and finally with the 4 - chloro pyrrolo pyrimidine condensation is obtained. The whole method raw materials are easy, simple operation, after treatment is easy, and the cost is low. (by machine translation)

Efficient and chemoselective reduction of pyridines to tetrahydropyridines and piperidines via rhodium-catalyzed transfer hydrogenation

Promoted by iodide anion the rhodium complex dimer, [Cp RhCl 2]2, catalyzes efficiently the transfer hydrogenation of various quaternary pyridinium salts under mild conditions, affording not only piperidines but also 1,2,3,6-tetrahydropyridines in a highly chemoselective fashion, depending on the substitution pattern at the pyridinium ring. The reduction is conducted in azeotropic formic acid/triethylamine (HCOOH-Et 3N) mixture at 40 °C, with catalyst loadings as low as 0.005mol% being feasible. Copyright

Achieving control over the branched/linear selectivity in palladium-catalyzed allylic amination

Palladium-catalyzed reaction of unsymmetrical allylic electrophiles with amines gives rise to regioisomeric allylic amines. We have found that linear products result from the thermodynamically controlled isomerization of the initially formed branched products. The isomerization is promoted by protic acid and active palladium catalyst. The use of base shuts down the isomerization pathway and allows for the preparation and isolation of branched allylic amines. Solvent plays a key role in achieving high kinetic regioselectivity and in controlling the rate of isomerization. The isomerization can be combined with ring-closing metathesis to afford the synthesis of exocyclic allylic amines from their endocyclic precursors.