95067-27-9

Usage

Uses

Used in Organic Synthesis:
METHYL 2-(ACETYLAMINO)-3-NITROBENZOATE is used as a building block in organic synthesis for the creation of various molecules and compounds due to its unique functional groups and reactivity.
Used in Pharmaceutical Research:
In Pharmaceutical Research, METHYL 2-(ACETYLAMINO)-3-NITROBENZOATE is used as a key component in the synthesis of certain pharmaceutical drugs, leveraging its potential biological and pharmacological activities to contribute to the development of new medications.
Used in Chemical Compound Development:
METHYL 2-(ACETYLAMINO)-3-NITROBENZOATE is employed in the development of new chemical compounds, where its structural features and properties are utilized to enhance or create novel chemical entities with specific applications in various industries.

InChI:InChI=1/C10H10N2O5/c1-6(13)11-9-7(10(14)17-2)4-3-5-8(9)12(15)16/h3-5H,1-2H3,(H,11,13)

Upstream product

• 108-24-7 acetic anhydride 
• 134-20-3 2-carbomethoxyaniline 
• 2719-08-6 methyl 2-(acetylamino)benzoate 

Downstream Products

• 5398-69-6 2-iodo-3-nitrobenzoic acid 
• 606-18-8 3-nitroanthranilic acid 
• 57113-91-4 methyl 3-nitroanthranilate 
• 942429-43-8 C₂₂H₁₈N₄O₅ 
• 942429-60-9 C₂₃H₂₁N₃O₇ 
• 942429-48-3 C₂₂H₁₈N₄O₂ 
• 942429-64-3 C₂₃H₂₁N₃O₄ 
• 908371-36-8 2'-(2-benzyloxy-phenyl)-1H,1'H-[2,4']bibenzoimidazolyl-4-carboxylic acid methyl ester 
• 908371-35-7 2-amino-3-{[2-(2-benzyloxy-phenyl)-1H-benzoimidazole-4-carbonyl]-amino}-benzoic acid methyl ester 
• 107582-20-7 2,3-diaminobenzoic acid methyl ester 
• 877070-04-7 2-[6-(3,4-dimethyl-phenyl)-pyridin-2-yl]-1H-benzoimidazole-4-carbaldehyde 
• 877070-05-8 {2-[6-(3,4-dimethyl-phenyl)-pyridin-2-yl]-1H-benzoimidazol-4-yl}-methanol 
• 877070-07-0 2-{2-[6-(3,4-dimethyl-phenyl)-pyridin-2-yl]-1H-benzoimidazol-4-ylmethylene}-malonic acid diethyl ester 

Relevant academic research and scientific papers

BICYCLIC COMPOUND AND PHARMACEUTICAL USE THEREOF

The present invention provides a compound represented by the formula wherein R1 is a hydrocarbon group optionally having substituent(s), amino optionally having substituent(s), hydroxy optionally having a substituent or a heterocyclic group optionally having substituent(s); R2 is a hydrogen atom or a hydrocarbon group optionally having substituent(s); Xa and Xb are each C, N, O or S; Xc and Xd are each C or N; m is 0-2; n is 1-3; ring A is a 5-membered ring optionally having substituent(s); ring B is a 6-membered ring optionally having substituent(s); and ring C is a 3- to 5-membered ring optionally having substituent(s), provided that when Xa, Xc and Xd are each C, then Xb is N or S, or a salt thereof, which is useful as an agent for the prophylaxis or treatment of a disease relating to an action of melatonin, and the like.

Synthesis and anticancer evaluation of bis(benzimidazoles), bis(benzoxazoles), and benzothiazoles

Four classes of UK-1 analogues were synthesized and their cytotoxicity testing against human A-549, BFTC-905, RD, MES-SA, and HeLa carcinoma cell lines was determined. The results revealed that UK-1 and four of these analogues (15-18) are potent against the cancer cell lines. In particular, compound 16 is more potent than UK-1 against A-549 and HeLa cell lines, and compounds 15, 17, and 18 selectively exhibit potent cytotoxic activity against the BFTV-905 cells (IC50 9.6 μM), A-549 cells (IC50 6.6 μM), and MES-SA cells (IC50 9.2 μM), respectively.

Non-nucleoside inhibitors of the hepatitis C virus NS5B polymerase: Discovery and preliminary SAR of benzimidazole derivatives

Benzimidazole 5-carboxamide derivatives from a combinatorial screening library were discovered as specific inhibitors of the NS5B polymerase of the hepatitis C virus (HCV). Initial hit-to-lead activities taking advantage of high-throughput parallel synthetic techniques, identified a 1,2-disubstituted benzimidazole 5-carboxylic acid scaffold as the minimum core for biological activity. Potent analogues in this series inhibit the polymerase at low micromolar concentrations and provide an attractive 'drug-like' lead structure for further optimization and the development of potential HCV therapeutics.

Synthesis and Chiroptical Properties of Bridged 2,2'-Diaminobiphenyl Derivatives

The relationship between c.d. spectra and the conformation of chiral 2,2'-diaminobiphenyls was investigated as a function of the torsion angle between the benzene ring planes.The molecular structures of (S)-(+)-4,5,6,7,11,12,13,14-octahydrobenzazocino