95068-22-7

Usage

Physical state

Clear, colorless liquid

Uses

a. Synthesis of pharmaceuticals
b. Reagent in organic chemical reactions
c. Production of fragrances
d. Intermediate in manufacturing agricultural chemicals

Synonyms

a. p-bromophenyl ethyl ether
b. 4-(ethoxymethyl) bromobenzene

Hazard classification

Classified as a hazardous substance

Handling precautions

Should be handled with caution due to potential health and environmental risks

Upstream product

• 64-17-5 ethanol 
• 589-15-1 1-bromomethyl-4-bromobenzene 
• 998-30-1 Triethoxysilane 
• 1122-91-4 4-bromo-benzaldehyde 
• 873-75-6 4-bromobenzenemethanol 
• 75-03-6 ethyl iodide 
• 2031-62-1 diethoxymethylane 

Downstream Products

• 57726-26-8 4-hydroxybenzyl ethyl ether 
• 1122-91-4 4-bromo-benzaldehyde 
• 84355-04-4 bis-(4-methoxy-benzyl)-sulfoxide 
• 38204-93-2 bis[(4-hydroxyphenyl)methylene]sulfide 
• 189639-17-6 4,4'-[sulfinylbis(methylene)]diphenol 
• 95068-23-8 4-(ethoxymethyl)benzaldehyde 
• 1351353-56-4 2-(4-(ethoxymethyl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 
• 1228101-64-1 3-(6-(4-(ethoxymethyl)phenyl)thieno[3,2-d]pyrimidin-4-ylamino)phenol 

Relevant academic research and scientific papers

[Fp*Fc][PF6]: A remarkable non-symmetric dinuclear cation in a very stable mixed-valent state

We report herein dicarbonyl(pentamethylcyclopentadienyl)(ferroceniumyl)iron hexafluorophosphate, which contains a dimetallic cation with a remarkably stable mixed-valent (MV) structure and unexpected redox features. The electronic structure of this compound is discussed in the light of the existing Hush model, which suggests an unusually strong electronic coupling between the two iron centers, despite the non-symmetric environment of the metallic centers. End-to-end charge delocalization is not the main contributor to the extra-large stability of this MV complex, which originates from electronic effects other than the energetic difference between the two MV redox isomers (ΔG0). This open-shell derivative has also been briefly tested as a catalyst in the reductive etherification of aldehydes by hydrosilanes.

Cosolvent-Promoted O-Benzylation with Silver(I) Oxide: Synthesis of 1′-Benzylated Sucrose Derivatives, Mechanistic Studies, and Scope Investigation

A cosolvent-promoted O-benzylation strategy with Ag2O was developed. The cosolvent consisting of CH2Cl2 and n-hexane can not only improve the reaction solubility for carbohydrates but also increase the benzylation efficiency. The formation of byproducts is greatly inhibited in the developed method. This method is simple, mild, and highly effective, and numerous 1′-benzylated sucrose derivatives were prepared including a photoreactive (trifluoromethyl)phenyldiazirine-based sucrose. The mechanisms of benzylation with primary and secondary benzyl bromides were also elaborated. Furthermore, the application scope with alcohols, glucose, and ribose derivatives was investigated.

ANTI-INFLAMMATORY COMPOUND HAVING INHIBITORY ACTIVITY AGAINST MULTIPLE TYROSINE KINASES AND PHARMACEUTICAL COMPOSITION CONTAINING SAME

The present invention is for the anti-inflammatory compounds that have an inhibitory activity against protein tyrosine kinases and their pharmaceutical composition(s) containing the compound as the active ingredient. Since the compounds of the present invention can inhibit multiple protein kinases associated with inflammatory diseases and immune disorders, they are useful for their prevention or treatment.

Reductive etherification of aldehydes photocatalyzed by dicarbonyl pentamethylcyclopentadienyl iron complexes

The reductive etherification of aldehydes can be performed by the reaction with dialkylmethylsilanes in the presence of new iron(II) piano-stool catalysts of general formula Cp*Fe(CO)2Ar (Cp * = η5-C5Me5; Ar = Ph, 4-C6H4OCH3, 4-C6H4CH 3, Fc). This transformation is promoted by UV light and affords a simple route for the preparation of unsymmetrical alkyl ethers.

Highly efficient indium-catalyzed chemoselective allylation-etherification and reductive etherification of aromatic aldehydes with functional silanes

Indium(III) chloride is an effective Lewis acid catalyst for one-pot allylation-etherification and reductive etherification of aromatic aldehydes with functional silanes, allyltriethoxysilane, and triethoxysilane, at room temperature to afford corresponding ethers in excellent yields. Additionally, the InCl3-catalyzed reactions in the presence of TMSCl offer significant advantages in its ease of working-up for the preparation of unsymmetrical ethers under mild conditions.

Benzodioxepine derivatives

This invention relates to compounds of the formula wherein B, X, Y, Z, R1 and R2 are as defined in the description, and pharmaceutically acceptable salts thereof. The invention further relates to pharmaceutical compositions containing such compounds, to a process for their preparation and to their use for the treatment and/or prevention of diseases which are modulated by ACCβ inhibitors.

BENZO [b][1,4] DIOXEPINE DERIVATIVES

This invention relates to compounds of the formula (I), wherein B, X, Y, Z, R1 and R2 are as defined in the description, and pharmaceutically acceptable salts thereof. The invention further relates to pharmaceutical compositions containing such compounds, to a process for their preparation and to their use for the treatment and/or prevention of diseases which are modulated by ACCβ inhibitors.

Anilide derivative, production and use thereof

This invention is to provide a compound of the formula: wherein R1is an optionally substituted 5- to 6-membered ring; the ring A is an optionally substituted 6- to 7-membered ring; the ring B is an optionally substituted benzene ring; n is an integer of 1 or 2; Z is a chemical bond or a divalent group; R2is (1) an optionally substituted amino group in which a nitrogen atom may form a quaternary ammonium, (2) an optionally substituted nitrogen-containing heterocyclic ring group which may contain a sulfur atom or an oxygen atom as ring constituting atoms and wherein a nitrogen atom may form a quaternary ammonium, (3) a group binding through a sulfur atom or (4) a group of the formula: ?wherein k is 0 or 1, and when k is 0, a phosphorus atom may form a phosphonium; and R5and R6are independently an optionally substituted hydrocarbon group, an optionally substituted hydroxy group or an optionally substituted amino group, and R5and R6may bind to each other to form a cyclic group together with the adjacent phosphorus atom, or a salt thereof , which is useful for antagonizing CCR5 and also for the prevention and treatment of infectious disease of HIV.

Correlation of the rates of solvolysis of (arylmethyl)methylphenyl-sulfonium ions

The specific rates of solvolysis of the benzylmethylphenylsulfonium ion (prepared as the trifluoromethanesulfonate salt) and five benzylic ring-substituted derivatives can be satisfactorily correlated using NT solvent nucleophilicity values. Addition of a secondary term, governed by the aromatic ring parameter (I), shows the sensitivities towards changes in this parameter to fall and those towards changes in NT to rise with increasing electron-withdrawing ability of the substituent. The Hammett ρ values with electron-withdrawing substituents (based on ρ+ values) vary from -0.9 in 95% acetone to -1.8 in 97% 2,2,2-trifluoroethanol. These Grunwald-Winstein and Hammett analyses are compared to those previously reported, with essentially the same solvents and substituents, for solvolyses of arylmethyl p-toluenesulfonates.