950683-55-3

Usage

Uses

Used in Bioconjugation:
t-Boc-N-Amido-PEG2-Azide is used as a bioconjugation agent for the attachment of various biomolecules, such as peptides, proteins, and nucleic acids, to other molecules or surfaces. The PEG spacer provides increased solubility and stability, while the azide group enables efficient and selective coupling through Click Chemistry.
Used in Drug Delivery Systems:
In the pharmaceutical industry, t-Boc-N-Amido-PEG2-Azide is used as a component in drug delivery systems to improve the pharmacokinetics and biodistribution of therapeutic agents. The PEGylation of drugs can enhance their solubility, circulation time, and bioavailability, while the azide group allows for the attachment of targeting ligands or imaging agents through Click Chemistry.
Used in Chemical Biology:
t-Boc-N-Amido-PEG2-Azide is employed as a building block in the development of chemical probes and tools for biological research. The PEG linker can be used to attach small molecules or other functional groups to biomolecules, enabling the study of their interactions and activities in cellular and molecular contexts.
Used in Materials Science:
In the field of materials science, t-Boc-N-Amido-PEG2-Azide is used as a component in the synthesis of functional polymers and materials. The PEG-based linker can be incorporated into polymer structures to impart properties such as hydrophilicity, biocompatibility, and self-assembly behavior, while the azide group allows for the subsequent attachment of other functional groups or moieties through Click Chemistry.

Upstream product

• 19249-03-7 triethylene glycol di-(p-toluenesulfonate) 
• 6338-55-2 2-(2-(2-aminoethoxy)ethoxy)ethan-1-ol 

Downstream Products

• 660843-23-2 1-{2-[2-(2-aminoethoxy)ethoxy]ethyl}-2,5-dihydro-1H-pyrrole-2,5-dione trifluoroacetate 
• 1253204-69-1 C₃₁H₃₅BF₂N₄O₆ 
• 153086-78-3 tert-butyl {2-[2-(2-aminoethoxy)ethoxy]ethyl}carbamate 
• 1312302-12-7 (S)-2-{2-[2-(tert-butoxycarbonylamino)ethoxy]ethoxy}ethyl 2-((2S,3R)-3-{[(9H-fluoren-9-yl)methoxy]carbonylamino}-2-hydroxy-4-phenyl-butanamido)-4-methylpentanamide 
• 1312302-13-8 (S)-tert-butyl 2-(2-{2-[4-methyl-2-(4-phenylbutanamido)pentanamido]ethoxy}ethoxy)ethyl-carbamate 
• 1312302-16-1 (2E,4E,6E,8E)-2-cyanoethyl 9-((E)-3-{2-[2-(2-{2-[(S)-2-((2S,3R)-3-{[(9H-fluoren-9-yl)methoxy]carbonylamino}-2-hydroxy-4-phenylbutanamido)-4-methylpentanamido]ethoxy}ethoxy)ethylamino]-2-oxoethoxyimino}-2,6,6-trimethylcyclohex-1-enyl)-3,7-dimethylnona-2,4,6,8-tetraenoate 
• 1312302-17-2 (2E,4E,6E,8E)-2-cyanoethyl 3,7-dimethyl-9-((E)-2,6,6-trimethyl-3-{2-[2-(2-{2-[(S)-4-methyl-2-(4-phenylbutanamido)pentanamido]ethoxy}ethoxy)ethylamino]-2-oxoethoxyimino}cyclohex-1-enyl)nona-2,4,6,8-tetraenoate 
• 1310451-45-6 (2E,4E,6E,8E)-9-[(E)-3-(2-{2-[2-(2-{(S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanamido]-4-methylpentanamido}ethoxy)ethoxy]ethylamino}-2-oxoethoxyimino)-2,6,6-trimethylcyclohex-1-enyl]-3,7-dimethylnona-2,4,6,8-tetraenoic acid 
• 1312302-18-3 C₅₉H₇₅N₅O₁₁ 
• 1312302-09-2 (2E,4E,6E,8E)-3,7-dimethyl-9-((E)-2,6,6-trimethyl-3-{2-[2-(2-{2-[(S)-4-methyl-2-(4-phenylbutanamido)pentanamido]ethoxy}ethoxy)ethylamino]-2-oxoethoxyimino}cyclohex-1-enyl)nona-2,4,6,8-tetraenoic acid 
• 1349193-23-2 N-[N₁-(8-tert-butoxycarbonylamino-3,6-dioxaoct-1-yl)-1,2,3-triazol-4-yl]methyl-N-[N₄-(benzyloxycarbonyl)cytosin-1-ylacetyl]glycine ethyl ester 
• 1349193-24-3 N-[N₁-(8-tert-butoxycarbonylamino-3,6-dioxaoct-1-yl)-1,2,3-triazol-4-yl]methyl-N-[N₆-(benzyloxycarbonyl)adenin-9-ylacetyl]glycineethyl ester 

Relevant academic research and scientific papers

COMPOUNDS COMPRISING CLEAVABLE LINKER AND USES THEREOF

Provided are a compound including a cleavable linker, a use thereof, and an intermediate compound for preparing the same, and more particularly, the compound including a cleavable linker of the present invention may include an active agent (for example, a drug, a toxin, a ligand, a probe for detection, etc.) having a specific function or activity, a -S(=0)(=N-)- functional group which is capable of selectively releasing the active agent, and a functional group which triggers a chemical reaction, a physicochemical reaction and/or a biological reaction by external stimulation, and may further include a ligand (for example, oligopeptide, polypeptide, antibody, etc.) having binding specificity for a desired target receptor.

IRAK DEGRADERS AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same.

Synthesis of N-propynyl analogues of peptide nucleic acid (PNA) monomers and their use in the click reaction to prepare N-functionalized PNAs

Application of the click reaction for coupling a 2-(2-aminoethoxy)ethoxy (AEE) function to thyminyl, cytosinyl and adeninyl peptide nucleic acid (PNA) monomer analogues bearing a N-propynyl group, in place of the original N-2-aminoethyl moiety, has been explored. The N-propynyl PNA analogues were prepared from glycine ethyl ester hydrochloride and the structure of the thyminyl derivative was confirmed by X-ray diffraction. These monomers were employed in click reactions with Boc-protected AEE azide to afford the corresponding triazolyl-linked PNA-AEE conjugates in yields ranging from 64 to 76%. [1,4]-Regiochemistry was verified from a NOESY correlation experiment.

Two-step labeling of endogenous enzymatic activities by Diels-Alder ligation

A ligation strategy based on the Diels-Alder [4+2] cycloaddition for the two-step activity-based labeling of endogenously expressed enzymes in complex biological samples has been developed. A panel of four diene-derivatized proteasome probes was synthesized, along with a dienophile-functionalized BODIPY(TMR) tag. These probes were applied in a Diels-Alder labeling procedure that enabled us to label active proteasome β-subunits selectively in cellular extracts and in living cells. We were also able to label the activity of cysteine proteases in cell extracts by utilizing a diene-derivatized cathepsin probe. Importantly, the Diels-Alder strategy described here is fully orthogonal with respect to the Staudinger-Bertozzi ligation, as demonstrated by the independent labeling of different proteolytic activities by the two methods in a single experiment.