950747-02-1

Upstream product

• 18162-48-6 tert-butyldimethylsilyl chloride 
• 950747-16-7 (S)-6-((4-methoxybenzyl)oxy)hex-1-yn-3-ol 
• 943859-07-2 (±)-6-(4-methoxybenzyloxy)hex-1-yn-3-ol 
• 119649-27-3 4-((4-methoxybenzyl)oxy)butanal 
• 950746-99-3 (S)-(+)-6-[(4-methoxybenzyl)oxy]-1-trimethylsilyl-1-hexyn-3-ol 
• 950746-98-2 6-[(4-methoxybenzyl)oxy]-1-trimethylsilyl-1-hexyn-3-one 
• 957300-51-5 (±)-6-(4-methoxybenzyloxy)-1-(trimethylsilyl)hex-1-yn-3-ol 

Downstream Products

• 950747-03-2 (1E,3S)-3-[(tert-butyldimethylsilyl)oxy]-1-iodo-6-[(4-methoxybenzyl)oxy]-1-hexene 
• 1026248-50-9 (Z)-(S)-7-[(1R,2R,3S,5S)-3-Benzyloxymethoxy-5-(tert-butyl-dimethyl-silanyloxy)-2-((Z)-oct-2-enyl)-cyclopentyl]-4-(tert-butyl-dimethyl-silanyloxy)-hept-5-enoic acid 
• 185114-50-5 1-[(Z)-(S)-7-[(1R,2R,3S,5S)-3-Benzyloxymethoxy-5-(tert-butyl-dimethyl-silanyloxy)-2-((Z)-oct-2-enyl)-cyclopentyl]-4-(tert-butyl-dimethyl-silanyloxy)-hept-5-enyloxymethyl]-4-methoxy-benzene 
• 950747-12-3 C₂₂H₄₃O₄Si₂SeC₆H₅ 

Relevant academic research and scientific papers

First total synthesis of modiolide A, based on the whole-cell yeast-catalyzed asymmetric reduction of a propargyl ketone

While the first total synthesis of modiolide A (1a), a 10-membered ring lactone with a marine-origin was achieved, an important chiral building block for constructing the chirality at C-4 in 1a, (S)-6-[(4-methoxybenzyl)oxy]-1-trimethylsilyl-1-hexyn-3-ol (

New marine prostanoids, preclavulone lactones, from the Okinawan soft coral Clavularia viridis

Two new marine prostanoids, preclavulone lactones I (1) and II (2) were isolated from the Okinawan soft coral, Clavularia viridis. Their structures were determined based on spectroscopic analysis and chemical synthesis from (S)-malic acid. Preclavulone lactones with side chains having absolute configurations opposite to those of mammalian prostanoids could be recognized as key intermediates in biosynthesis of clavulones.