950778-43-5Relevant articles and documents
Synthesis of benzo[1,2-d;3,4-d′]diimidazole and 1H-pyrazolo[4,3-b] pyridine as putative A2A receptor antagonists
Piersanti, Giovanni,Giorgi, Luca,Bartoccini, Francesca,Tarzia, Giorgio,Minetti, Patrizia,Gallo, Grazia,Giorgi, Fabrizio,Castorina, Massimo,Ghirardi, Orlando,Carminati, Paolo
, p. 2567 - 2571 (2007)
The synthesis and the binding affinity for the putative adenosine receptor antagonist 6-methyl-7-[1,2,3]triazol-2-yl-1,6-dihydrobenzo[1,2-d;3,4-d′] diimidazole (10) and 5-oxazol-2-yl-1H-pyrazolo[4,3-b]pyridin-3-ylamine (16) are reported. The title compounds were prepared from commercially available 1-chloro-2,4-dinitrobenzene (1) and 2-chloro-6-methoxy-3nitropyridine (11), respectively, but proved devoid of affinity for the adenosine A1 and A2A receptors. The Royal Society of Chemistry.
