950838-19-4Relevant articles and documents
Optically pure γ-butyrolactones and epoxy esters via two stereocentered HKR of 3-substituted epoxy esters: A formal synthesis of (-)-paroxetine, Ro 67-8867 and (+)-eldanolide
Devalankar, Dattatray A.,Karabal, Pratibha U.,Sudalai, Arumugam
supporting information, p. 1280 - 1285 (2013/05/08)
The HKR of racemic anti- or syn-3-substituted epoxy esters catalyzed by a Co(iii)salen complex provides ready access to the corresponding enantioenriched 3,4-disubstituted γ-butyrolactones and 3-substituted epoxy esters. This strategy has been successfully employed in the formal synthesis of biologically active 3,4-disubstituted piperidine derivatives, (-)-paroxetine and Ro 67-8867 and a natural product, (+)-eldanolide.
Stereoselective rhodium-catalyzed conjugate addition of boronic acids to unprotected δ-hydroxy-γ-butenolides. Synthesis of (-)-7-oxamuricatacin and β-substituted derivatives
Navarro, Cristina,Moreno, Ana,Csák?, Aurelio G.
supporting information; experimental part, p. 466 - 469 (2009/04/10)
(Chemical Equation Presented) The chiral δ-hydroxy-γ-butanolide moiety is widely found among biologically active natural products. We report herein the stereoselective synthesis of β-substituted analogues of these compounds by the Rh1-catalyzed