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1423027-25-1

(3R,4S)-1-benzyl-4-(4-fluorophenyl)piperidin-3-ol is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 1423027-25-1 Structure

  • Basic information

    1. Product Name: (3R,4S)-1-benzyl-4-(4-fluorophenyl)piperidin-3-ol
    2. Synonyms: (3R,4S)-1-benzyl-4-(4-fluorophenyl)piperidin-3-ol
    3. CAS NO:1423027-25-1
    4. Molecular Formula:
    5. Molecular Weight: 285.361
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1423027-25-1.mol
    9. Article Data: 2

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: (3R,4S)-1-benzyl-4-(4-fluorophenyl)piperidin-3-ol(CAS DataBase Reference)
    10. NIST Chemistry Reference: (3R,4S)-1-benzyl-4-(4-fluorophenyl)piperidin-3-ol(1423027-25-1)
    11. EPA Substance Registry System: (3R,4S)-1-benzyl-4-(4-fluorophenyl)piperidin-3-ol(1423027-25-1)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1423027-25-1(Hazardous Substances Data)

1423027-25-1 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1423027-25-1 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,4,2,3,0,2 and 7 respectively; the second part has 2 digits, 2 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1423027-25:
(9*1)+(8*4)+(7*2)+(6*3)+(5*0)+(4*2)+(3*7)+(2*2)+(1*5)=111
111 % 10 = 1
So 1423027-25-1 is a valid CAS Registry Number.

1423027-25-1Relevant articles and documents

Core modification of substituted piperidines as Novel inhibitors of HDM2-p53 protein-protein interaction

Pan, Weidong,Lahue, Brian R.,Ma, Yao,Nair, Latha G.,Shipps Jr., Gerald W.,Wang, Yaolin,Doll, Ronald,Bogen, Stéphane L.

, p. 1983 - 1986 (2014/04/17)

The discovery of 3,3-disubstituted piperidine 1 as novel p53-HDM2 inhibitors prompted us to implement subsequent SAR follow up directed towards piperidine core modifications. Conformational restrictions and further functionalization of the piperidine core were investigated as a strategy to gain additional interactions with HDM2. Substitutions at positions 4, 5 and 6 of the piperidine ring were explored. Although some substitutions were tolerated, no significant improvement in potency was observed compared to 1. Incorporation of an allyl side chain at position 2 provided a drastic improvement in binding potency.

Optically pure γ-butyrolactones and epoxy esters via two stereocentered HKR of 3-substituted epoxy esters: A formal synthesis of (-)-paroxetine, Ro 67-8867 and (+)-eldanolide

Devalankar, Dattatray A.,Karabal, Pratibha U.,Sudalai, Arumugam

supporting information, p. 1280 - 1285 (2013/05/08)

The HKR of racemic anti- or syn-3-substituted epoxy esters catalyzed by a Co(iii)salen complex provides ready access to the corresponding enantioenriched 3,4-disubstituted γ-butyrolactones and 3-substituted epoxy esters. This strategy has been successfully employed in the formal synthesis of biologically active 3,4-disubstituted piperidine derivatives, (-)-paroxetine and Ro 67-8867 and a natural product, (+)-eldanolide.

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