95086-97-8

Usage

Uses

Used in Pharmaceutical Research and Development:
4-AMINO-N-(2-METHOXYETHYL)BENZAMIDE is used as a chemical intermediate for the synthesis of pharmaceuticals and organic compounds. Its unique structure allows it to be a versatile building block in the development of new drugs and therapeutic agents.
Used in Organic Chemistry:
In the field of organic chemistry, 4-AMINO-N-(2-METHOXYETHYL)BENZAMIDE is used as a reagent or starting material for various chemical reactions. Its methoxyethyl substituent and benzamide core provide opportunities for further functionalization and modification, making it a valuable component in the synthesis of complex organic molecules.
Used in Medicinal Chemistry:
4-AMINO-N-(2-METHOXYETHYL)BENZAMIDE is employed as a lead compound in medicinal chemistry. Its potential pharmacological or biological activities make it a promising candidate for further optimization and development into effective therapeutic agents.
Used in Drug Discovery:
In the drug discovery process, 4-AMINO-N-(2-METHOXYETHYL)BENZAMIDE is used as a screening compound to identify potential drug candidates. Its unique chemical properties and interactions with biological targets can provide insights into the development of new therapeutic agents.
Used in Chemical Synthesis:
4-AMINO-N-(2-METHOXYETHYL)BENZAMIDE is utilized in chemical synthesis for the preparation of various organic compounds. Its methoxyethyl group and benzamide structure offer opportunities for further reactions and modifications, making it a valuable component in the synthesis of a wide range of organic molecules.

InChI:InChI=1/C10H14N2O2/c1-14-7-6-12-10(13)8-2-4-9(11)5-3-8/h2-5H,6-7,11H2,1H3,(H,12,13)

Upstream product

• 67-56-1 methanol 
• 19614-29-0 1-(p-nitrobenzoyl)aziridine 
• 95086-96-7 N-(2-methoxyethyl)-p-nitrobenzamide 
• 62-23-7 4-nitro-benzoic acid 
• 122-04-3 4-nitro-benzoyl chloride 

Downstream Products

• 1229653-24-0 C₂₁H₂₉N₃O₃ 
• 1395885-91-2 N₄-(2-chlorophenyl)-N₂-[4-N-(2-methoxyethyl)carbamoylphenyl]pyrimidine-2,4-diamine hydrochloride 

Relevant academic research and scientific papers

Development of o-chlorophenyl substituted pyrimidines as exceptionally potent aurora kinase inhibitors

The o-carboxylic acid substituted bisanilinopyrimidine 1 was identified as a potent hit (Aurora A IC50 = 6.1 ± 1.0 nM) from in-house screening. Detailed structure-activity relationship (SAR) studies indicated that polar substituents at the para position of the B-ring are critical for potent activity. X-ray crystallography studies revealed that compound 1 is a type I inhibitor that binds the Aurora kinase active site in a DFG-in conformation. Structure-activity guided replacement of the A-ring carboxylic acid with halogens and incorporation of fluorine at the pyrimidine 5-position led to highly potent inhibitors of Aurora A that bind in a DFG-out conformation. B-Ring modifications were undertaken to improve the solubility and cell permeability. Compounds such as 9m with water-solubilizing moieties at the para position of the B-ring inhibited the autophosphorylation of Aurora A in MDA-MB-468 breast cancer cells.

AURORA KINASE INHIBITORS AND METHODS OF MAKING AND USING THEREOF

Described herein are inhibitors of Aurora kinase and their use in the treatment of cancer. Methods of screening for selective inhibitors of Aurora kinases are also disclosed.

COMPOUNDS AND METHODS

Disclosed are compounds having the formula (I): wherein R1, R2, R3, R4, R5, and R6 are as defined herein, and methods of making and using the same.

Exploration of secondary and tertiary pharmacophores in unsymmetrical N,N′-diaryl urea inhibitors of soluble epoxide hydrolase

The impact of various secondary and tertiary pharmacophores on in vitro potency of soluble epoxide hydrolase (sEH) inhibitors based on the unsymmetrical urea scaffold 1 is discussed. N,N′-Diaryl urea inhibitors of soluble epoxide hydrolase exhibit subtle variations in inhibitory potency depending on the secondary pharmacophore but tolerate considerable structural variation in the second linker/tertiary pharmacophore fragment.

Effect of para-Substituents on the Photochemical Rin-opening Reactivity of 1-(p-Substituted-benzoyl)aziridines in Methanol

Photolysis of 1-(p-substituted-benzoyl)aziridines (1a-e) in Ar-purged methanol led to N-(2-methoxyethyl)benzamides (3b-e) as the methanolysis products and/or N-ethylbenzamides (2a and b).Penta-1,3-diene quenched the formation of (2a and b) but not (3b-e).