950918-55-5Relevant articles and documents
Design, synthesis and biological evaluation of thrombin inhibitors based on a pyridine scaffold
Blomberg, David,Fex, Tomas,Xue, Yafeng,Brickmann, Kay,Kihlberg, Jan
, p. 2599 - 2605 (2008/02/14)
A series of 2,4-disubstituted pyridine derivatives has been designed, synthesised and evaluated as thrombin inhibitors. A Grignard exchange reaction was used to introduce various benzoyl substituents in position 4 of the pyridine ring, where they serve as