951-08-6Relevant academic research and scientific papers
Inhibition of Cryptosporidium parvum in vitro by 9-(alkylthio)acridine derivatives
Khalifa, Latifa,Rosales, Maria-Jose,Mascaro, Carmen,Karolak-Wojciechowska, Janina,Bsiri, Nadia,Brouant, Pierre,Barbe, Jacques
, p. 163 - 166 (2007/10/03)
The synthesis of several acridinic thioethers is described. Compounds prepared were tested in vitro as potential drugs against the opportunistic infection known as cryptosporidiosis. With a view to predict activity, the quantitative structure-activity relationships were investigated. Correlations between experimental data and either log P or pKa are discussed.
Nucleophilic attack on 2,1-benzisothiazolium salts
McKinnon, David M.,Duncan, K. Ann,Millar, Lesley M.
, p. 440 - 444 (2007/10/02)
2,1-benzisothiazolium salts react with several stabilized carbanions to give products that are derived by attack at the carbon atom of the heterocyclic ring.
ETUDE COMPARATIVE DE LA REACTIVITE DES ACRIDANONES, DES AMINOACRIDINES ET DES THIOACRIDANONES VIS-A-VIS DES AGENTS D'ALKYLATION DANS LES CONDITIONS DE LA CATALYSE PAR TRANSFERT DE PHASE
Galy, J. P.,Vincent, E. J.,Galy, A. M.,Barbe, J.,Elguero, J.
, p. 947 - 954 (2007/10/02)
This paper describes the results obtained in the alkylation of thioacridanone under phase transfer catalysis conditions.Nine different alkylating agents have been used and in all the cases the thioether was the sole product obtained.Proton and carbon-13 n.m.r. study of the different compounds has been carried out, giving an useful criteria to differentiate thioethers and thioacridanones.The HSAB principle has been used to discuss the relative amounts of 9- and 10- substituted isomers obtained from acridanones, aminoacridines and thioacridanones using different alkylating and acylating agents.
