95107-87-2Relevant academic research and scientific papers
A Horner-Wittig approach of S,N-ketene acetals. Acid-catalyzed hydrolysis of S,N-ketene acetals to (S)-thioesters
Otten, Pieter A.,Oskam, Njord,Van Der Gen, Arne
, p. 11095 - 11104 (2007/10/03)
The synthesis of S,N-acetals of formyldiphenylphosphine oxide 2 is described. The stable lithiated anions of these acetals were applied in a Horner-Wittig reaction with several structural types of aldehydes. The resulting S,N-ketene acetals 1 were obtaine
The reaction of α-amino-substituted diphenylphosphine oxide anions with elemental sulfur and selenium. A new route to thio- and selenoamides
Otten, P. A.,Gen, A. van der
, p. 499 - 506 (2007/10/02)
The lithiated anions of α-amino-substituted diphenylphosphine oxides 1, in which R can be hydrogen, aryl, alkyl and alkenyl, react with two equivalents of sulfur or selenium to form thio- and selenoamides, which can be isolated in good to excellent yields
The synthesis of α-amino-substituted diphenylphosphine oxides
Broekhof, N. L. J. M.,Elburg, P. van,Gen, A. van der
, p. 312 - 316 (2007/10/02)
Four methods with differing but overlapping specificity are described for the synthesis of α-unsubstituted as well as α-substituted (aminomethyl)diphenylphosphine oxides.The first method is based on the Arbusov reaction, the second on a Mannich-type condensation of diphenylphosphine oxide with aldehydes and secondary amines, the third on the addition of Ph2P(O)H to enamines and the fourth on the reaction of anions derived from α-unsubstituted (aminomethyl)diphenylphosphine oxides with various electrophiles.
