951127-24-5

Basic information

• Product Name: tert-butyl (2R,3S)-5-oxo-2-(2,4,5-trifluorophenyl)tetrahydro-2H-pyran-3-ylcarbamate
• Synonyms: tert-butyl (2R,3S)-5-oxo-2-(2,4,5-trifluorophenyl)tetrahydro-2H-pyran-3-ylcarbamate;Carbamic acid, N-[(2R,3S)-tetrahydro-5-oxo-2-(2,4,5-trifluorophenyl)-2H-pyran-3-yl]-, 1,1-dimethylethyl ester
• CAS NO: 951127-24-5
• Molecular Formula: C₁₆H₁₈F₃NO₄
• Molecular Weight: 345.3136296
• Mol File: 951127-24-5.mol
• Article Data: 10

Chemical Properties

• Appearance: /
• CAS DataBase Reference: tert-butyl (2R,3S)-5-oxo-2-(2,4,5-trifluorophenyl)tetrahydro-2H-pyran-3-ylcarbamate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl (2R,3S)-5-oxo-2-(2,4,5-trifluorophenyl)tetrahydro-2H-pyran-3-ylcarbamate(951127-24-5)
• EPA Substance Registry System: tert-butyl (2R,3S)-5-oxo-2-(2,4,5-trifluorophenyl)tetrahydro-2H-pyran-3-ylcarbamate(951127-24-5)

Safety Data

• Hazardous Substances Data: 951127-24-5(Hazardous Substances Data)

Usage

General Description

Tert-butyl (2R,3S)-5-oxo-2-(2,4,5-trifluorophenyl)tetrahydro-2H-pyran-3-ylcarbamate is a chemical compound that is primarily used in the field of pharmaceuticals and medicinal chemistry. It is a carbamate derivative with a tetrahydro-2H-pyran ring structure and a trifluorophenyl moiety, making it a potentially useful molecule for biological applications. The tert-butyl group attached to the carbamate enhances the compound's stability and solubility, while the presence of the trifluorophenyl group may confer specific pharmacological properties. The stereochemistry of the compound, with a 2R,3S configuration, is important for its biological activity and potential interactions with target proteins or receptors. Overall, tert-butyl (2R,3S)-5-oxo-2-(2,4,5-trifluorophenyl)tetrahydro-2H-pyran-3-ylcarbamate has the potential to be a valuable tool in drug discovery and development efforts.

Upstream product

• 1172623-95-8 (±)-tert-butyl (1-(methoxy(methyl)amino)-1-oxopent-4-yn-2-yl)carbamate 
• 61172-66-5 2-((tert-butoxycarbonyl)amino)pent-4-ynoic acid 
• 100860-41-1 ethyl 2-aminopent-4-ynoate 
• 951127-23-4 tert-butyl [(2R,3S)-5-hydroxy-5-(hydroxymethyl)-2-(2,4,5-trifluorophenyl)tetrahydro-2H-pyran-3-yl]carbamate 
• 156152-90-8 2-nitro-1-(2,4,5-trifluorophenyl)ethanone 
• 156152-89-5 phenyl 2,4,5-trifluorobenzoate 
• 951127-22-3 tert-butyl [(2R,3S)-5-methylene-2-(2,4,5-trifluorophenyl)tetrahydro-2H-pyran-3-yl]carbamate 
• 951127-21-2 (2R,3S)-5-methylene-2-(2,4,5-tri fluorophenyl)tetrahydro-2H-pyran-3-amine 
• 951127-20-1 (2R,3S)-5-methylene-3-nitro-2-(2,4,5-trifluorophenyl)tetrahydro-2H-pyran 
• 951127-18-7 3-methylene-5-nitro-6-(2,4,5-trifluorophenyl)-3,4-dihydro-2H-pyran 
• 24424-99-5 di-tert-butyl dicarbonate 
• 88419-56-1 2,4,5-trifluorobenzoyl chloride 

Downstream Products

• 1226781-94-7 tert-Butyl {(2R,3S,5R)-2-(2,4,5-trifluorophenyl)-5-[2-(cyclopropylsulfonyl)-2,6-dihydropyrrolo[3,4-c]pyrazol-5(4H)-yl]tetrahydro-2H-pyran-3-yl}carbamate 
• 1226781-88-9 tert-Butyl {(2R,3S,5R)-2-(2,4,5-Trifluorophenyl)-5-[2-(methylsulfonyl)-2,6-dihydropyrrolo[3,4-c]pyrazol-5(4H)-yl]tetrahydro-2H-pyran-3-yl}carbamate 
• 1226781-91-4 tert-Butyl {(2R,3S,5R)-2-(2,4,5-trifluorophenyl)-5-[2-(cyclopentylsulfonyl)-2,6-dihydropyrrolo[3,4-c]pyrazol-5(4H)-yl]tetrahydro-2H-pyran-3-yl}carbamate 

Relevant articles and documents

AMINO PYRANOID RING DERIVATIVE AND COMPOSITION AND USE THEREOF

The present invention relates to an amino pyran ring derivative and a composition and use thereof, and in particular, to an amino pyran ring derivative represented by general formula (I) or a stereoisomer, a pharmaceutically acceptable salt or a prodrug thereof, a pharmaceutical composition comprising the derivative, and their medical use in the manufacture of a di-peptidyl peptidase IV (DPP-IV) inhibitor, in formula (I) the substituents are defined the same as those in the specification.

Aminopyran ring derivative and its composition and application wherein the dipeptidyl peptidase IV (DPP-IV) inhibitor is used for preparing the drugs for treating metabolic diseases

The present invention relates to an aminopyran ring derivative and its composition and application, specifically speaking, relating to the aminopyran ring derivative represented by the general formula (I) or its stereoisomer, pharmaceutically acceptable salt, prodrug, pharmaceutical composition containing the derivative and the preparation of dipeptidyl peptidase IV (DPP-IV) inhibitor for medical use, wherein the definitions of the substituents in the general formula (I) are the same as those defined in the patent specification.

AMINOTETRAHYDROPYRANS AS DIPEPTIDYL PEPTIDASE-IV INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES

The present invention is directed to novel substituted aminotetrahydropyrans of structural formula I which are inhibitors of the dipeptidyl peptidase-IV enzyme and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly Type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.