951127-31-4

Basic information

• Product Name: [(2R,3S)-5-methylene-2-(2,5-difluorophenyl)tetrahydro-2H-pyran-3-yl]carbamic acid tert-butyl ester
• Synonyms: [(2R,3S)-5-methylene-2-(2,5-difluorophenyl)tetrahydro-2H-pyran-3-yl]carbamic acid tert-butyl ester
• CAS NO: 951127-31-4
• Molecular Weight: 325.355
• Mol File: 951127-31-4.mol
• Article Data: 13

Chemical Properties

• CAS DataBase Reference: [(2R,3S)-5-methylene-2-(2,5-difluorophenyl)tetrahydro-2H-pyran-3-yl]carbamic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: [(2R,3S)-5-methylene-2-(2,5-difluorophenyl)tetrahydro-2H-pyran-3-yl]carbamic acid tert-butyl ester(951127-31-4)
• EPA Substance Registry System: [(2R,3S)-5-methylene-2-(2,5-difluorophenyl)tetrahydro-2H-pyran-3-yl]carbamic acid tert-butyl ester(951127-31-4)

Safety Data

• Hazardous Substances Data: 951127-31-4(Hazardous Substances Data)

Usage

Description

[(2R,3S)-5-methylene-2-(2,5-difluorophenyl)tetrahydro-2H-pyran-3-yl]carbamic acid tert-butyl ester is a complex chemical compound with the molecular formula C15H19F2NO3. It is characterized by a tetrahydro-2H-pyran-3-yl moiety, a six-membered heterocyclic ring containing oxygen and carbon atoms, and a 2,5-difluorophenyl group along with a methylene substituent. This unique structure contributes to the compound's distinctive chemical properties, which may have significant implications in the fields of medicinal chemistry, pharmaceuticals, and agrochemicals. Further research is necessary to fully comprehend its potential applications and properties.

Uses

Used in Pharmaceutical Industry:
[(2R,3S)-5-methylene-2-(2,5-difluorophenyl)tetrahydro-2H-pyran-3-yl]carbamic acid tert-butyl ester is used as a key intermediate for the synthesis of various pharmaceutical compounds. Its unique chemical structure allows for the development of new drugs with potential applications in treating a wide range of medical conditions.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, [(2R,3S)-5-methylene-2-(2,5-difluorophenyl)tetrahydro-2H-pyran-3-yl]carbamic acid tert-butyl ester serves as a valuable compound for studying its interactions with biological targets. Understanding these interactions can lead to the discovery of novel therapeutic agents and contribute to the advancement of drug design strategies.
Used in Agrochemical Development:
[(2R,3S)-5-methylene-2-(2,5-difluorophenyl)tetrahydro-2H-pyran-3-yl]carbamic acid tert-butyl ester may also find applications in the agrochemical industry. Its unique properties could be harnessed for the development of new pesticides, herbicides, or other agricultural chemicals that can improve crop yield and protect plants from pests and diseases.

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 951127-27-8 1-(2,5-difluorophenyl)-2-nitroethanone 
• 951127-30-3 (2R,3S)-2-(2,5-difluorophenyl)-5-methylenetetrahydro-2H-pyran-3-amine 
• 951127-29-0 (2R,3S)-5-methylidenyl-3-nitro-2-(2,5-difluorophenyl)tetrahydro-2H-pyran 
• 951127-28-9 6-(2,5-difluorophenyl)-3-methylidene-5-nitro-3,4-dihydro-2H-pyran 

Downstream Products

• 1107693-22-0 C₁₆H₁₈F₂N₄O 
• 951127-32-5 [(2R,3S)-5-hydroxy-5-hydroxymethyl-2-(2,5-difluorophenyl)tetrahydro-2H-pyran-3-yl]carbamic acid tert-butyl ester 
• 951127-25-6 N-[(2R,3S)-2-(2,5-difluorophenyl)tetrahydro-5-oxo-2H-pyran-3-yl]carbamic acid 1,1-dimethylethyl ester 
• 1107484-78-5 tert-butyl ((2R,3S,5S)-2-(2,5-difluorophenyl)-5-(pyrrolo[3,4-c]-pyrazol-5(1H,4H,6H)-yl)tetrahydro-2H-pyran-3-yl)carbamate 
• 1601482-70-5 tert-butyl ((2R,3S,5R)-2-(2,5-difluorophenyl)-5-(5-(methylsulfonyl)-hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)tetrahydro-2H-pyran-3-yl)carbamate 
• 1601479-72-4 (2R,3S,5R)-2-(2,5-difluorophenyl)-5-(5-(methylsulfonyl)hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)tetrahydro-2H-pyran-3-amine 
• 1601482-71-6 tert-butyl ((2R,3S,5R)-2-(2,5-difluorophenyl)-5-(7-(methylsulfonyl)-2,7-diazaspiro[4.4]nonan-2-yl)tetrahydro-2H-pyran-3-yl)carbamate 
• 1601479-75-7 (2R,3S,5R)-2-(2,5-difluorophenyl)-5-(7-(methylsulfonyl)-2,7-diazaspiro[4.4]nonan-2-yl)tetrahydro-2H-pyran-3-amine 

Relevant articles and documents

AMINOTETRAHYDROPYRAN DERIVATIVE USED AS DIPEPTIDYL PEPTIDASE-IV INHIBITOR

Provided is an Aminotetrahydropyran derivative represented by general formula (I), a preparation method for the derivative, a pharmaceutical composition containing the derivative, and the use of the derivative to prepare a therapeutic agent, especially a dipeptidyl peptidase-IV inhibitor.

Inhibitor for dipeptidyl peptidase-IV

The invention provides an aminotetrahydropyran derivative with a general formula (I) as described in the specification, pharmaceutically acceptable salts, hydrates, solvates and stereoisomers thereof, a preparation method for the aminotetrahydropyran derivative, and a pharmaceutical composition containing the aminotetrahydropyran derivative. The aminotetrahydropyran derivative provided by the invention can inhibit the activity of dipeptidyl peptidase-IV(DPP-IV), and can be used for treatment of diseases related to dipeptidyl peptidase-IV, especially for treatment of diabetes.

Aminotetrahydropyran derivative used as dipeptidyl peptidase-IV inhibitor

The invention provides an aminotetrahydropyran derivative as shown in the general formula (I), pharmaceutically acceptable salt, hydrate, solvate and stereisomer of the derivative, a preparation method thereof, and a pharmaceutical composition containing the compound. The compound can inhibit activity of dipeptidyl peptidase IV (DPP-IV) and can be used in treating diseases related to dipeptidyl peptidase IV.