1107693-22-0

Basic information

• Product Name: C₁₆H₁₈F₂N₄O
• CAS NO: 1107693-22-0
• Molecular Weight: 320.342
• Mol File: 1107693-22-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₆H₁₈F₂N₄O(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₆H₁₈F₂N₄O(1107693-22-0)
• EPA Substance Registry System: C₁₆H₁₈F₂N₄O(1107693-22-0)

Safety Data

• Hazardous Substances Data: 1107693-22-0(Hazardous Substances Data)

Upstream product

• 951127-27-8 1-(2,5-difluorophenyl)-2-nitroethanone 
• 1280210-79-8 2,6-dihydropyrrole [3,4-c]pyrazole-5(4H)-carboxylic acid tert-butyl ester 
• 1107484-78-5 tert-butyl ((2R,3S,5S)-2-(2,5-difluorophenyl)-5-(pyrrolo[3,4-c]-pyrazol-5(1H,4H,6H)-yl)tetrahydro-2H-pyran-3-yl)carbamate 
• 951127-25-6 N-[(2R,3S)-2-(2,5-difluorophenyl)tetrahydro-5-oxo-2H-pyran-3-yl]carbamic acid 1,1-dimethylethyl ester 
• 951127-31-4 [(2R,3S)-5-methylene-2-(2,5-difluorophenyl)tetrahydro-2H-pyran-3-yl]carbamic acid tert-butyl ester 
• 951127-30-3 (2R,3S)-2-(2,5-difluorophenyl)-5-methylenetetrahydro-2H-pyran-3-amine 
• 951127-29-0 (2R,3S)-5-methylidenyl-3-nitro-2-(2,5-difluorophenyl)tetrahydro-2H-pyran 
• 951127-28-9 6-(2,5-difluorophenyl)-3-methylidene-5-nitro-3,4-dihydro-2H-pyran 

Relevant articles and documents

Novel tetrahydropyran analogs as dipeptidyl peptidase IV inhibitors: Profile of clinical candidate (2R,3S,5R)-2-(2,5-difluorophenyl)-5-[2- (methylsulfonyl)-2,6-dihydropyrrolo[3,4-c]pyrazol-5(4H)-yl]tetrahydro-2H-pyran- 3-amine (23)

A series of novel tri-2,3,5-substituted tetrahydropyran analogs were synthesized and evaluated as inhibitors of dipeptidyl peptidase IV (DPP-4) for the treatment of type 2 diabetes. Optimization of the series provided inhibitors with good DPP-4 potency and selectivity over other peptidases (QPP, DPP8, and FAP). Compound 23, which is very potent, selective, efficacious in the diabetes PD model, and has an excellent pharmacokinetic profile, is selected as a clinical candidate.