95123-17-4

Upstream product

• 1501-26-4 methyl 4-(chlorocarbonyl)butyrate 
• 588-72-7 [(E)-2-bromoethenyl]benzene 
• 1431525-86-8 C₇H₁₁IO₃ 
• 104227-38-5 methyl 6-(dimethoxyphosphoryl)-5-oxohexanoate 
• 100-52-7 benzaldehyde 
• 76700-85-1 6-Chlor-5-oxo-hexancarbonsaeuremethylester 

Downstream Products

• 33407-50-0 (E)-5-oxo-7-phenylhept-6-enoic acid 

Relevant academic research and scientific papers

5-Oxo-ETE receptor antagonists

5-Oxo-ETE is the most powerful eosinophil chemoattractant among lipid mediators. Eosinophil infiltration into the lungs of asthmatics may be responsible for the late phase of inflammatory asthma. We have designed and synthesized a 5-oxo-ETE receptor antagonist, the purpose of which is to prevent eosinophil migration to the lung during an asthma attack and thereby reduce asthma symptoms.

Metallic Nickel-Mediated Synthesis of Ketones by the Reaction of Benzylic, Allylic, Vinylic, and Pentafluorophenyl Halides with Acid Halides

Metallic nickel was investigated as a convenient coupling reagent for the synthesis of ketones by the reaction of benzylic, allylic, vinylic, and pentafluorophenyl halides with acid halides at 85 deg C in glyme.A variety of benzylic ketones with functional groups including halogen, cyano, methoxycarbonyl, and hydroxycarbonyl groups were prepared in good yields by this method.The reaction was demonstrated to proceed via organonickel halide intermediates formed by the smooth oxidative addition of benzylic and acyl halides to metallic nickel, which were trapped with electron-deficient olefins. (?-Allyl)nickel halides, prepared in situ at 85 deg C from allylic halides and the nickel, also worked for the preparation of ketones.Vinylic and pentafluorophenyl halides but not alkyl halides reacted with acid halides to give the corresponding ketones in moderate yields.

Base-induced Novel Ring-opening of 2-Alkyl-2-chloro-1,3-cyclohexanedione

2-Chloro derivatives (4a-c) of 1,3-cyclohexanedione give open chain methyl esters (5a-c) with the retention of chloro substituent, upon treatment with sodium acetate in methanol.