104227-38-5

Usage

Uses

Used in Pharmaceutical Industry:
Dimethyl-5-mehtoxycarbonyl-2-oxopentyl phosphonate, 98%, is utilized as a key intermediate in the synthesis of pharmaceutical compounds for its ability to contribute to the development of novel drugs with enhanced efficacy and selectivity.
Used in Agrochemical Industry:
In the agrochemical sector, Dimethyl-5-mehtoxycarbonyl-2-oxopentyl phosphonate, 98%, serves as a crucial component in the creation of innovative agrochemicals, including pesticides and herbicides, due to its role in enhancing the activity and selectivity of these products.
Used in Chemical Synthesis:
Dimethyl-5-mehtoxycarbonyl-2-oxopentyl phosphonate, 98%, is employed as a versatile building block in organic synthesis for its capacity to form a wide range of organic molecules with diverse applications across various industries, underpinned by its high purity and reliable performance.

Upstream product

• 67-56-1 methanol 
• 87517-46-2 dimethyl 2-oxo-5-(carbo-tert-butoxy)pentanephosphonate 
• 186581-53-3 diazomethane 
• 108-55-4 glutaric anhydride, 
• 756-79-6 dimethyl methane phosphonate 
• 76700-85-1 6-Chlor-5-oxo-hexancarbonsaeuremethylester 
• 121-45-9 phosphorous acid trimethyl ester 
• 904691-68-5 1-methylpentafluorophenyl pentanedioate 
• 13433-42-6 dimethyl α-trimethylsilylmethylphosphonate 
• 1501-27-5 Pentanedioic acid, monomethyl ester 
• 1431525-86-8 C₇H₁₁IO₃ 
• 59378-98-2 5-tert-butyl methyl glutarate 
• 1501-26-4 methyl 4-(chlorocarbonyl)butyrate 
• 96-36-6 methyl phosphite 

Downstream Products

• 95123-17-4 (E)-5-Oxo-7-phenyl-hept-6-enoic acid methyl ester 
• 202916-64-1 Benzoic acid (1S,2R,3R,4R)-3-((E)-6-methoxycarbonyl-3-oxo-hex-1-enyl)-2-((Z)-oct-2-enyl)-4-(tetrahydro-pyran-2-yloxy)-cyclopentyl ester 

Relevant academic research and scientific papers

New Syntheses of Some Functionalized and Acetylenic β-Keto Phosphonates

β-Keto phosphonates ω-functionalized by an ester group 1a-f, by a hydroxyl 5, and with a triple bond conjugated to the carbonyl group 2a-c were prepared by reacting dimethyl (lithiomethyl)phosphonate (3) with adequate electrophiles.Cyclic anhydrides such as succinic and glutaric anhydrides were employed for the synthesis of the two first homologs 1a and 1b.To obtain the other longer homologs 1c-f, 3-acylthiazolidine-2-thiones 7a-d easily prepared using cheap 2-mercaptothiazoline proved to be the electrophiles of choice.On the other hand, the synthesis of keto phosphonates 2a-c required the use of N-methoxy-N-methylamides.

5-Oxo-ETE receptor antagonists

5-Oxo-ETE is the most powerful eosinophil chemoattractant among lipid mediators. Eosinophil infiltration into the lungs of asthmatics may be responsible for the late phase of inflammatory asthma. We have designed and synthesized a 5-oxo-ETE receptor antagonist, the purpose of which is to prevent eosinophil migration to the lung during an asthma attack and thereby reduce asthma symptoms.

Chemoselective synthesis of β-ketophosphonates using lithiated α-(trimethylsilyl)methylphosphonate

A highly chemoselective synthesis of β-ketophosphonates from pentafluorophenyl esters and lithiated methyl α-(trimethylsilyl)methylphosphonate has been developed. This mild lithiated phosphonate reagent allows the synthesis of functionalized β-ketophosphonates in the presence of unactivated esters with high yields. This method has been compared with the standard lithiated methylphosphonate reagent.

Prostanoids: LXVI. A priori Postulated "9-LO Prostanoids"

Based on the analysis of the literature data and the results given here, suggestions were made as to the pharmacological potential of "9-LO prostanoids." One representative of this class of compounds, (+)-2-decarboxy-2-ethyl-19,20-dinor-18-carboxyprostaglandin F2α, was synthesized starting from (-)-7α-hydroxy-6β-hydroxymethyl-cis-2-oxabicyclo[3.3.1]octan-3-one.

Total synthesis of a novel isoprostane IPF(2α)-I and its identification in biological fluids

The first tokai synthesis of IPF(2α)-I 25 is described using D-glucose as starting material. This novel isoprostane has been used to establish its presence in human urine.