95128-29-3

Upstream product

• 100627-66-5 C₂₀H₁₇NO₂ 
• 4397-53-9 p-benzyloxybenzaldehyde 
• 95-55-6 2-amino-phenol 
• 3539-95-5 2-[(2-benzyloxy-phenylimino)-methyl]-phenol 

Downstream Products

• 3315-19-3 2-(4-hydroxyphenyl)benzoxazole 

Relevant academic research and scientific papers

One-pot green synthesis of benzoxazole derivatives through molecular sieve-catalyzed oxidative cyclization reaction

An one-pot approach to benzoxazole ring from 2-aminophenol and aldehydes utilizing molecular sieve as the catalyst have been developed. The new oxidative cyclization reaction excluded the usage of hazardous chemical reagents, transition-metal catalysts, chemical oxidants, or strong acids, and, therefore, reduced the production of toxic chemical waste. This offers an environmentally friendly pathway for the synthesis of various benzoxazole derivatives.

Synthesis, DNA-binding ability and anticancer activity of benzothiazole/benzoxazole-pyrrolo[2,1-c][1,4]benzodiazepine conjugates

A series of benzothiazole and benzoxazole linked pyrrolobenzodiazepine conjugates attached through different alkane or alkylamide spacers was prepared. Their anticancer activity, DNA thermal denaturation studies, restriction endonuclease digestion assay and flow cytometric analysis in human melanoma cell line (A375) were investigated. One of the compounds of the series 17d showed significant anticancer activity with promising DNA-binding ability and apoptosis caused G0/G1 phase arrest at sub-micromolar concentrations. To ascertain the binding mode and understand the structural requirement of DNA binding interaction, molecular docking studies using gold program and more rigorous 2 ns molecular dynamic simulations using Molecular Mechanics-Poisson-Boltzman Surface Area (MM-PBSA) approach including the explicit solvent were carried out. Further, the compound 17d was evaluated for in vivo efficacy studies in human colon cancer HT29 xenograft mice.