3315-19-3

Basic information

• Product Name: 4-(1,3-benzoxazol-2-yl)benzenol
• Synonyms: 4-(1,3-benzoxazol-2-yl)benzenol;4-BENZOOXAZOL-2-YL-PHENOL;Zinc03101849;4-(BENZO[D]OXAZOL-2-YL)PHENOL
• CAS NO: 3315-19-3
• Molecular Formula: C₁₃H₉NO₂
• Molecular Weight: 211.219
• Mol File: 3315-19-3.mol
• Article Data: 46

Chemical Properties

• Melting Point: 250 °C(Solv: water (7732-18-5); ethanol (64-17-5))
• Boiling Point: 355.8±25.0 °C(Predicted)
• Appearance: /
• Density: 1.293±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 8.89±0.15(Predicted)
• CAS DataBase Reference: 4-(1,3-benzoxazol-2-yl)benzenol(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(1,3-benzoxazol-2-yl)benzenol(3315-19-3)
• EPA Substance Registry System: 4-(1,3-benzoxazol-2-yl)benzenol(3315-19-3)

Safety Data

• Hazardous Substances Data: 3315-19-3(Hazardous Substances Data)

Usage

General Description

4-(1,3-benzoxazol-2-yl)benzenol, also known as 2-hydroxy-4-(2'-hydroxyphenyl)benzoxazole, is a chemical compound that belongs to the class of benzoxazole derivatives. It is a white to off-white powder that is soluble in organic solvents such as methanol and ethyl acetate. 4-(1,3-benzoxazol-2-yl)benzenol has diverse applications in the field of pharmaceuticals, and it is used as a building block in the synthesis of various pharmaceutical drugs. Additionally, it has shown potential as a fluorescence probe for the detection of metal ions in analytical and environmental chemistry. However, it is important to handle this compound with caution as it may pose health hazards if not handled properly.

Upstream product

• 767-00-0 4-cyanophenol 
• 95-55-6 2-amino-phenol 
• 123-08-0 4-hydroxy-benzaldehyde 
• 95128-29-3 2-[4-(benzyloxy)phenyl]-1,3-benzoxazole 
• 402-45-9 4-hydroxybenzotrifluoride 
• 623-05-2 (4-hydroxyphenyl)methanol 
• 273-53-0 benzoxazole 
• 540-38-5 p-Iodophenol 
• 106-41-2 4-bromo-phenol 
• 615-36-1 2-bromoaniline 
• 28141-24-4 4-hydroxybenzoyl chloride 
• 100-09-4 4-methoxybenzoic acid 
• 90-04-0 2-methoxy-phenylamine 
• 7464-55-3 N-(o-methoxyphenyl)-4-methoxybenzamide 

Downstream Products

• 838-34-6 2-(p-methoxyphenyl)benzoxazole 
• 1236771-70-2 2-[4-(5-bromopentyloxy)phenyl]-1,3-benzoxazole 

Relevant articles and documents

Synthesis, Characterization and DFT-D Studies of 2-Aminoethoxycalix[4]resorcinarenes: A Novel Heterogeneous Organocatalyst

The present article reports the synthesis of two novel supramolecular architectures, Phenyl(octa-2-aminoethoxy)calix[4]resorcinarene and 2-Aminoethoxyphenyl-(octa-2-aminoethoxy)calix[4]resorcinarene via surface functionalization and describes their applic

2-Aryl benzazole derived new class of anti-tubercular compounds: Endowed to eradicate mycobacterium tuberculosis in replicating and non-replicating forms

The high mortality rate and the increasing prevalence of Mtb resistance are the major concerns for the Tuberculosis (TB) treatment in this century. To counteract the prevalence of Mtb resistance, we have synthesized 2-aryl benzazole based dual targeted molecules. Compound 9m and 9n were found to be equally active against replicating and non-replicating form of Mtb (MIC(MABA) 1.98 and 1.66 μg/ml; MIC(LORA) 2.06 and 1.59 μg/ml respectively). They arrested the cell division (replicating Mtb) by inhibiting the GTPase activity of FtsZ with IC50 values 45 and 64 μM respectively. They were also capable of kill Mtb in non-replicating form by inhibiting the biosynthesis of menaquinone which was substantiated by the MenG inhibition (IC50 = 11.62 and 7.49 μM respectively) followed by the Vit-K2 rescue study and ATP production assay.

Development of homogeneous polyamine organocatalyst for the synthesis of 2-aryl-substituted benzimidazole and benzoxazole derivatives

A new polyamine was prepared by the ring opening polymerization of epichlorohydrin and properly characterized. The catalytic property of the prepared polymer was assessed by synthesizing 2-aryl-substituted benzimidazole and benzoxazole derivatives by the conjugation of o-phenylenediamine/o-aminophenol with various aromatic aldehydes in the presence of atmospheric oxygen. Significant attributes of the present synthesis include short reaction time, good to excellent yield, high purity, easy reusability, and room temperature reaction. The reaction was carried out in the absence of any metal catalyst and other cooxidants.