951385-91-4Relevant academic research and scientific papers
Application of Pd(0)-catalyzed intramolecular oxazine formation to the efficient total synthesis of ( - )-anisomycin
Joo, Jae-Eun,Lee, Kee-Young,Pham, Van-Thoai,Tian, Yong-Shou,Ham, Won-Hun
, p. 3627 - 3630 (2008/02/12)
The enantioselective total synthesis of ( - )-anisomycin, a potent antibiotic agent, has been achieved. The key steps are a Pd(0)-catalyzed stereoselective intramolecular oxazine formation from D-tyrosine and pyrrolidine formation by catalytic hydrogenation of the oxazine.
