93634-70-9

Upstream product

• 75437-11-5 (Z)-N-benzoylamino-3-(4-methyoxyphenyl) acrylic acid methyl ester 
• 7479-01-8 O-methyl-tyrosine methyl ester; hydrochloride 
• 98-88-4 benzoyl chloride 
• 7635-29-2 O-methyl tyrosine 

Downstream Products

• 951385-88-9 (R)-N-(1-(methoxy(methyl)amino)-3-(4-methoxyphenyl)-1-oxopropan-2-yl)benzamide 
• 951385-82-3 (R)-N-(1-hydroxy-3-(4-methoxyphenyl)propan-2-yl)benzamide 
• 951385-91-4 C₃₆H₄₀ClNO₃Si 
• 951385-81-2 N-((2R,3R,E)-3-(tert-butyldimethylsilyloxy)-6-chloro-1-(4-methoxyphenyl)hex-4-en-2-yl)benzamide 
• 951385-95-8 C₂₀H₂₂ClNO₃ 
• 951385-90-3 N-((2R,3S,E)-6-chloro-3-hydroxy-1-(4-methoxyphenyl)hex-4-en-2-yl)benzamide 
• 951385-89-0 (R,E)-N-(6-chloro-1-(4-methoxyphenyl)-3-oxohex-4-en-2-yl)benzamide 
• 951385-87-8 (4R,5R)-5-((E)-3-chloroprop-1-enyl)-4-(4-methoxybenzyl)-2-phenyl-4,5-dihydrooxazole 

Relevant academic research and scientific papers

A new type of chiral-pyridoxamines for catalytic asymmetric transamination of α-keto acids

A new type of chiral pyridoxamines bearing an adjacent chiral stereocenter has been developed via multi-step synthesis. The pyridoxamines displayed catalytic activity in asymmetric transamination of α-keto acids to give a variety of optically active amino acids in 27–78% yields with 34–62% ee's under very mild conditions. This work provides a synthetic strategy to construct new chiral pyridoxamines using bromopyridine 7 as a key synthon and also represents an early example of the applications of chiral pyridoxamines in asymmetric catalysis.

Highly efficient rhodium/monodentate phosphoramidite catalyst and its application in the enantioselective hydrogenation of enamides and α-dehydroamino acid derivatives

An easily prepared and highly efficient monodentate phosphoramidite ligand derived from BINOL, (S)2,2-(1,1-binaphthyl)-dioxo-N,N-diethylphospholidine, was examined in the hydrogenation of both enamides and α-dehydroamino acid derivatives. The catalyst pro

A comparison of the asymmetric hydrogenation catalyzed by rhodium complexes containing chiral ligands with a binaphthyl unit and those with a 5,5′,6,6′,7,7′,8,8′-octahydro-binaphthyl unit

The chiral ligands H8-BINAPO and H8-BDPAB were synthesized by reacting chlorodiphenylphosphine with H8-BINOL and H8-BINAM, respectively. Applications of these ligands in the Rh-catalyzed enantioselective hydrogenation of a variety of (Z)-acetamido-3-arylacrylic acid methyl esters provided chiral amino acid derivatives with good to excellent enantioselectivities (H8-BINAPO: up to 84.0% e.e.; H8-BDPAB: up to 97.1% e.e.). In the hydrogenation of acetamidoacrylic acid, 99% e.e. was obtained when a [Rh(H8-BDPAB)]+ catalyst was used. The catalytic activities and enantioselectivities of [Rh(H8-BINAPO)]+ and [Rh(H8-BDPAB]+ are substantially better than those obtained with the corresponding rhodium catalysts containing BINAPO (up to 64% e.e.) and BDPAB (up to 92.6% e.e.).

UNUSUAL AMINO ACIDS. III. ASYMMETRIC SYNTHESIS OF 3-ARYLALANINES

21 (Z)-α-N-benzoylamino-β-arylacrylic acids and their esters were prepared by known procedures and hydrogenated to the corresponding optically active α-benzoyl-β-arylalanine derivatives with optical yields in the range of 82-95percent ee using the cationi