951950-35-9Relevant academic research and scientific papers
Reducing the Flexibility of Type II Dehydroquinase for Inhibition: A Fragment-Based Approach and Molecular Dynamics Study
Peón, Antonio,Robles, Adrián,Blanco, Beatriz,Convertino, Marino,Thompson, Paul,Hawkins, Alastair R.,Caflisch, Amedeo,González-Bello, Concepción
, p. 1512 - 1524 (2017)
A multidisciplinary approach was used to identify and optimize a quinazolinedione-based ligand that would decrease the flexibility of the substrate-covering loop (catalytic loop) of the type II dehydroquinase from Helicobacter pylori. This enzyme, which i
One-pot synthesis of 2-amino-4(3H)-quinazolinones via ring-opening of isatoic anhydride and palladium-catalyzed oxidative isocyanide-insertion
Ji, Fei,Lv, Mei-Fang,Yi, Wen-Bin,Cai, Chun
, p. 5766 - 5772 (2014/07/22)
An efficient and practical two-step process has been developed for the synthesis of 2-amino-4(3H)-quinazolinones via ring-opening of isatoic anhydride and palladium-catalyzed oxidative isocyanide-insertion in one pot. This regioselective procedure could construct a wide range of 2-amino-4(3H)- quinazolinones in moderate to excellent yields. Furthermore, the methodology also had distinct advantages of easily accessible starting materials and operational simplicity. the Partner Organisations 2014.
