952-75-0

Usage

Chemical class

Pyridine derivative

Mechanism of action

Potent serotonin reuptake inhibitor

Function

Increases levels of serotonin in the brain

Medical use

Antidepressant and mood stabilizer

Effective for

Treating major depressive disorder and other mood disorders

Working principle

Blocks the reuptake of serotonin at the synapses, increasing its availability in the brain

Additional potential

Therapeutic agent for a range of neurological and psychiatric conditions
This list provides a concise overview of the key properties and uses of 1-(2-oxo-2-phenylethyl)pyridin-2(1H)-one, based on the information provided.

Upstream product

• 6273-90-1 N-phenacyl-2-chloropyridinium bromide 
• 142-08-5 2-Pyridone 
• 70-11-1 α-bromoacetophenone 
• 7732-18-5 water 
• 7664-41-7 ammonia 
• 68-12-2 N,N-dimethyl-formamide 
• 109-00-2 3-HYDROXYPYRIDINE 
• 5633-34-1 (benzoylmethylene)dimethylsulfurane 
• 20912-84-9 Diphenylsulfonium phenacylid 
• 20718-17-6 2-(dimethyl(oxo)-λ⁶-sulfaneylidene)-1-phenylethan-1-one 
• 142-08-5 2-hydroxypyridin 

Downstream Products

• 109514-80-9 1-(2-phenyl-[1,3]dioxolan-2-ylmethyl)-1H-pyridin-2-one 
• 69914-21-2 1-(2-hydroxy-2-phenylethyl)-1,2-dihydropyridin-2-one 
• 108664-23-9 1-(1-Benzoyl-vinyl)-1H-pyridin-2-one 
• 120491-79-4 3,5-Dibromo-1-(2-oxo-2-phenyl-ethyl)-1H-pyridin-2-one 
• 120491-80-7 3,5-Diiodo-1-(2-oxo-2-phenyl-ethyl)-1H-pyridin-2-one 
• 120491-84-1 3-Bromo-1-(1,1-dibromo-2-oxo-2-phenyl-ethyl)-1H-pyridin-2-one 

Relevant academic research and scientific papers

Ruthenium-catalyzed chemoselective N?H bond insertion reactions of 2-pyridones/7-azaindoles with sulfoxonium ylides

A ruthenium-catalyzed highly chemoselective N-alkylation of 2-pyridones has been developed, affording N-alkylated 2-pyridone derivatives in good yields and excellent N-selectivity. The key to achieve this unprecedented N?H rather than O?H insertion reaction is the use of CpRu(PPh3)2Cl as the catalyst and sulfoxonium ylides as the alkylation reagents. Moreover, this protocol is also amenable to 7-azaindoles by slightly varying the reaction conditions. Furthermore, sulfonium ylides are also suitable alkylation reagents, providing the N-alkylated 2-pyridones in good selectivity.

Route exploration and synthesis of the reported pyridone-based PDI inhibitor STK076545

The enzyme protein disulfide isomerase (PDI) is essential for the correct folding of proteins and the activation of certain cell surface receptors, and is a promising target for the treatment of cancer and thrombotic conditions. A previous high-throughput screen identified the commercial compound STK076545 as a promising PDI inhibitor. To confirm its activity and support further biological studies, a resynthesis was pursued of the reported β-keto-amide with an N-alkylated pyridone at the α-position. Numerous conventional approaches were complicated by undesired fragmentations or rearrangements. However, a successful 5-step synthetic route was achieved using an aldol reaction with an α-pyridone allyl ester as a key step. An X-ray crystal structure of the final compound confirmed that the reported structure of STK076545 was achieved, however its lack of PDI activity and inconsistent spectral data suggest that the commercial structure was misassigned.

Environmentally benign nucleophilic substitution reaction of arylalkyl halides in water using CTAB as the inverse phase transfer catalyst

An environmentally benign, practically scalable and highly selective C-arylalkylation of active methylene compounds is developed using CTAB as the inverse phase transfer catalyst in water. The methodology developed is elaborated into the one-pot synthesis of quinoline derivatives and also applicable to the regioselective N-aralkyl of 2-pyridones.

Specific N-Alkylation of Hydroxypyridines Achieved by a Catalyst- and Base-Free Reaction with Organohalides

A specific N-alkylation of 2-hydroxypyridines is achieved by reacting with organohalides under catalyst- and base-free conditions. The observed HX-facilitated conversion of pyridyl ether intermediates to 2-pyridone products may account for the success and

COMPOSITION FOR MAINTAINING PLATELET FUNCTION

Provided is a composition for maintaining a function of platelets, having as an active ingredient a pyridone derivative represented by the following general formula (I), or a salt thereof (in the formula, ring A, R1, R2, R3/sup

PYRIDONE DERIVATIVE AND MEDICINE CONTAINING SAME

General formula (I): The present invention pertains to: a pyridone derivate or a salt thereof represented by general formula (I); or a medicine containing the pyridone derivative or salt thereof as an active ingredient. [In the formula, ring A, R1/s

Synthesis and Antifungal Activity of a Series of Novel 1,2-Disubstituted Propenones

To find an antifungal agent other than those of the imidazole and triazole series, a new class of 1,2-disubstituted propenones I and II was prepared and tested for antifungal activity.Comparison of the structure-activity relationships showed that the conjugated structure of carbonyl and exomethylene groups in I and II plays an important role in potent antifungal acivity.However, it is noteworthy that compounds 53, 54, and 56, which have a hydroxymethyl or methoxymethyl group instead of an exo-methylene group in I, also showed potent activity.Although many compounds exhibited strong antifungal activity in vitro, none showed activity in vivo of oral efficacy against subacute systemic candidiasis in mice. '

ALKYLATION OF 2-HYDROXYBENZOTHIAZOLE SALTS

The alkylation reactions of 2-hydroxybenzothiazole salts with various alkyl halides afford the N-alkylated derivatives.With alkyl halides prone to molecular reactions, 2-hydroxybenzothiazole in the presence of silver carbonate, yields N- and O-alkylated p