95201-24-4

Upstream product

• 36997-05-4 2-methoxyacrylic acid ethyl ester 
• 1614-00-2 (E)-N-(4-nitrobenzylidene)aniline 
• 62-53-3 aniline 
• 555-16-8 4-nitrobenzaldehdye 
• 623-47-2 propynoic acid ethyl ester 
• 91-56-5 indole-2,3-dione 
• 100-19-6 (4-nitrophenyl)ethanone 

Downstream Products

• 70097-13-1 2-(4-nitrophenyl)quinoline-4-carboxylic acid 

Relevant academic research and scientific papers

Aromatic Annelation by Reaction of Arylimidoyl Radicals with Alkynes: a New Synthesis of Quinolines

An easily effected aromatic annelation is described, involving the reaction of arylimidoyl radicals with alkynes to give quinolines.

Rapid synthesis of quinoline-4-carboxylic acid derivatives from arylimines and 2-substituted acrylates or acrylamides under indium(III) chloride and microwave activations. Scope and limitations of the reaction

Rapid synthesis of quinoline-4-carboxylic acid derivatives has been achieved by reaction of 2-methoxy acrylates or acrylamides with N-arylbenzaldimines in acetonitrile under InCl3 catalysis and microwave irradiation. Isolated yields up to 57% within 3 min have been obtained. The Lewis acid and the microwave activation appeared as crucial parameters for the reaction. The role of indium chloride and ytterbium triflate was specified using 13C NMR data and model theoretical studies. The Royal Society of Chemistry 2005.