95217-40-6Relevant articles and documents
Investigations of the generality of quaternary ammonium salts as alkylating agents in direct C-H alkylation reactions: Solid alternatives for gaseous olefins
Sch?nbauer, David,Spettel, Manuel,Pollice, Robert,Pittenauer, Ernst,Schnürch, Michael
supporting information, p. 4024 - 4030 (2019/04/29)
C-H alkylation reactions using short chain olefins as alkylating agents could be operationally simplified on the lab scale by using quaternary ammonium salts as precursors for these gaseous reagents: Hofmann elimination delivers in situ the desired alkenes with the advantage that the alkene concentration in the liquid phase is high. In case a catalytic system did not tolerate the conditions for Hofmann elimination, a very simple spatial separation of both reactions, Hofmann elimination and direct alkylation, was achieved to circumvent possible side reactions or catalyst deactivation. Additionally, the truly catalytically active species of a rhodium(i) mediated alkylation reaction could be identified by using this approach.
Chiral lithium amide mediated asymmetric synthesis of 3-aryl-3,4- dihydroisocoumarins
Sharma, Arvind Kumar,Maheshwary, Yogita,Singh, Paramjit,Singh, Kamal Nain
experimental part, p. 54 - 62 (2010/10/19)
An asymmetric synthesis of 3-aryl-3,4-dihydroisocoumarins using the reaction of laterally lithiated 4,4-dimethyl-2-(o-tolyl)oxazoline with aromatic aldehydes, in the presence of an external chiral ligand, gave products with enantiomeric excess (ee) in the range of 60-70%. ARKAT USA, Inc.
