952424-11-2Relevant academic research and scientific papers
ORGANIC COMPOUNDS
-
Page/Page column 198, (2008/06/13)
The present invention relates to compounds of the formula; and their use in therapy.
Designed double-strand DNA cleavage with chelate-appended porphyrins
Groves, John T.,Matsunaga, Akio
, p. 1595 - 1600 (2007/10/03)
The first example of DNA double-strand cleavage mediated by a synthetic porphyrin is described. Two new porphyrins, each with two metal complexing appendages, were shown to mediate the oxidative double-strand cleavage of pBR322 plasmid DNA. By contrast, a porphyrin with one appendage was found to mediate only single-strand breaks.
