952579-60-1Relevant academic research and scientific papers
FACTOR XIa INHIBITORS
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Page/Page column 57, (2016/11/02)
The present invention provides a compound of Formula (I); and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XIa inhibitors or dual inhibitors of Factor XIa and plasma kallikrein.
A concise total synthesis of the purported structure of flossonol
Guignard, Rapha?lf.
supporting information, p. 157 - 160 (2013/02/25)
We report the first total synthesis of flossonol in only five steps and of one of its isomers in seven steps using a radical addition/cyclization sequence as the key step. Comparison of our spectroscopic data with those of the literature indicates a misas
Investigation of the reaction of α-thioamides, α-esters and α-nitriles with N-halosuccinimides
Kissane, Marie,Murphy, Maureen,Lynch, Denis,Ford, Alan,Maguire, Anita R.
, p. 7639 - 7649 (2008/12/20)
Investigation of the reaction of α-thioamides, α-esters and α-nitriles with NBS and NCS is described. The?scope of this stereoselective oxidative transformation to the β-haloacrylamides, β-acrylates and β-acrylonitriles has been determined. A mechanistic
Discovery of (-)-6-[2-[4-(3-fluorophenyl)-4-hydroxy-1-piperidinyl]-1-hydroxyethyl]-3,4-dihydro-2(1H)-quinolinone-A potent NR2B-selective N-methyl d-aspartate (NMDA) antagonist for the treatment of pain
Kawai, Makoto,Ando, Kazuo,Matsumoto, Yukari,Sakurada, Isao,Hirota, Masako,Nakamura, Hiroshi,Ohta, Atsuko,Sudo, Masaki,Hattori, Kazunari,Takashima, Tadashi,Hizue, Masanori,Watanabe, Shuzo,Fujita, Isami,Mizutani, Mayumi,Kawamura, Mitsuhiro
, p. 5558 - 5562 (2008/04/07)
(-)-6-[2-[4-(3-Fluorophenyl)-4-hydroxy-1-piperidinyl]-1-hydroxyethyl]-3,4-dihydro-2(1H)-quinolinone was identified as an orally active NR2B-subunit selective N-methyl-d-aspartate (NMDA) receptor antagonist. It has very high selectivity for NR2B subunits c
