95274-12-7

Usage

InChI:InChI=1/C14H19NO2/c1-17-14(16)9-13-7-8-15(11-13)10-12-5-3-2-4-6-12/h2-6,13H,7-11H2,1H3

Upstream product

• 67-56-1 methanol 
• 55278-09-6 (1-benzyl-3-pyrrolidinyl)-acetonitrile 
• 775-16-6 N-benzyl-3-pyrrolidinone 
• 7732-18-5 water 
• 75-36-5 acetyl chloride 

Downstream Products

• 95274-14-9 3-pyrrolidinacetic acid methyl ester 

Relevant academic research and scientific papers

PROGRANULIN MODULATORS AND METHODS OF USING THE SAME

Provided herein are compounds that modulate progranulin and methods of using the compounds in progranulin-associated disorders, such as Frontotemporal dementia (FTD).

LTA4 Hydrolase inhibitors

The present invention provides compounds of the formula Ar1-Q-Ar2-Y-R-Z and pharmaceutically acceptable salts thereof wherein Ar1 and Ar2 are optionally substituted aryl moieties, Z is an optionally substituted nitrogen-containing moiety which may be an acyclic, cyclic or bicyclic amine or an optionally substituted monocyclic or bicyclic nitrogen-containing heteroaromatic moiety; Q is a linking group capable of linking two aryl groups; R is an alkylene moiety; Y is a linking moiety capable of linking an aryl group to an alkylene moiety and wherein Z is bonded to R through a nitrogen atom. The compounds and pharmaceutical compositions of the present invention are useful in the treatment of inflammatory diseases which are mediated by LTB4 production, such as proriasis, ulcerative colitis, IBD and asthma.

4-substituted 1,2,4-triazole derivatives

A discrete class of 4-substituted 1,2,4-triazole derivatives are selective agonists of 5-HT 1 -like receptors and are therefore useful in the treatment of clinical conditions, in particular migraine and associated disorders, for which a selective agonist of these receptors is indicated.

4-Substituted 1,2,4-triazole derivatives

4-substituted 1,2,4-triazole derivatives of formula I: wherein R represents a 2-(dimethylamino)ethyl group, or a group of formula (i) or (ii): or a salt or prodrug thereof;, are selective agonists of 5-HT1-like receptors and are therefore useful in the treatment of clinical conditions, in particular migraine and associated disorders, for which a selective agonist of these receptors is indicated.

N-Substituted pyrrolidineacetic acids and their esters

N-Substituted pyrrolidineacetic acids and their esters, useful as inhibitors of GABA uptake, are prepared by reacting an appropriate N-alkylating derivative with an esters of an N-unsubstituted pyrrolidineacetic acid followed by hydrolysis of the ester.

Orally Active and Potent Inhibitors of γ-Aminobutyric Acid Uptake

3-Pyrrolidineacetic acid (1a), certain piperidinecarboxylic acids - i.e., piperidinecarboxylic acid (2a), 1,2,5,6-tetrahydro-3-pyridinecarboxylic acid (3a), and cis-4-hydroxy-3-piperidinecarboxylic acid (4a) - cis-3-aminocyclohexanecarboxylic acid (5a, ci