95278-74-3

Upstream product

• 59046-72-9 o-(phenylethynyl)benzaldehyde 
• 241813-23-0 N-tert-butyl-1-(2-(phenylethynyl)phenyl)methylenamine 
• 109-73-9 N-butylamine 
• 94744-39-5 1-oxo-2-phenyl-1H-indene-3-carbonitrile 
• 536-74-3 phenylacetylene 
• 40400-15-5 2-(2-iodophenyl)acetonitrile 

Relevant academic research and scientific papers

Cs2CO3 Catalyzed Intramolecular Aminocarbonylation of Alkynes: Synthesis of 3-Amino-1H-inden-1-ones from N-tert-Butyl-2-(1-alkynyl)benzaldimines

Synthesis of a wide variety of 3-amino-1H-inden-1-ones from N-tert-butyl-2-(1-alkynyl)benzaldimines via intramolecular aminocarbonylation of alkynes using Cs2CO3 as catalyst and air as oxidant has been developed. This highly atom-efficient, transition-metal-free reaction proceeds under thermal conditions. We propose that the reaction proceeds through an unprecedented 5-exo-dig cyclization of N-tert-butyl-2-(1-alkynyl)benzaldimines and thermal rearrangement of 3-methylene-2λ2-isoindolin-1-ols. (Figure presented.).

Palladium(ii)-catalyzed synthesis of functionalized indenones via oxidation and cyclization of 2-(2-arylethynylphenyl)acetonitriles

A one-pot two-step synthesis of versatile indenones has been developed. This palladium(ii)-catalyzed transformation involves generation and condensation of ortho-functionalized 1,2-benzils from 2-(2-arylethynylphenyl)acetonitriles using Ph2SO as the oxidant. The resulting 3-cyanoindenones can be converted to various valuable molecules.