95333-92-9Relevant articles and documents
One-step double covalent functionalization of reduced graphene oxide with xanthates and peroxides
Pennetreau, Florence,Riant, Olivier,Hermans, Sophie
supporting information, p. 15009 - 15012 (2015/02/19)
Radical functionalization of reduced graphene oxide has been achieved by reaction with a xanthate in the presence of peroxide as a radical initiator. X-ray photoelectron spectroscopy, bulk elemental analyses, and thermogravimetric analyses showed that the
Potent pyrrolidine- and piperidine-based BACE-1 inhibitors
Iserloh,Wu,Cumming,Pan,Wang,Stamford,Kennedy,Kuvelkar,Chen,Parker,Strickland,Voigt
, p. 414 - 417 (2008/04/03)
Based on lead compound 1 identified from the patent literature, we developed novel patentable BACE-1 inhibitors by introducing a cyclic amine scaffold. Extensive SAR studies on both pyrrolidines and piperidines ultimately led to inhibitor 2f, one of the m
NOVEL ISOPHTHALATES AS BETA-SECRETASE INHIBITORS
-
Page/Page column 29, (2010/11/23)
There is provided a series of substituted isophthalates of formula (I) or a stereoisomer thereof; or a pharmaceutically acceptable salt thereof, wherein W, R3, R5 and R6 as defined herein, their pharmaceutical compositions and methods of use. These novel compounds inhibit the processing of amyloid precursor protein (APP) by β-secretase and, more specifically, inhibit the production of Aβ-peptide. The present disclosure is directed to compounds useful in the treatment of neurological disorders related to β-amyloid production, such as Alzheimer's disease and other conditions affected by anti-amyloid activity.
